Self-Assembled Lipoplexes of Short Interfering RNA (siRNA) Using Spermine-Based Fatty Acid Amide Guanidines: Effect on Gene Silencing Efficiency [PDF]
Pharmaceutics, 2011 Four guanidine derivatives of N4,N9-diacylated spermine have been designed, synthesized, and characterized. These guanidine-containing cationic lipids bound siRNA and formed nanoparticles. Two cationic lipids with C18 unsaturated chains, N1,N12-diamidino-
Abdelkader A. Metwally +1 more
doaj +5 more sources
Observation of guanidine-carbon dioxide complexation in solution and its role in reaction of carbon dioxide and propargylamines [PDF]
, 2014 The first observation of guanidine-CO2 'activation' complexes in solution using ATR-FTIR is reported. While cyclic guanidines TBD and MTBD form stable and detectable complexes with CO2, other guanidines and tertiary amines do not.
Kaufhold, S, Nguyen, BN, Nicholls, R
core +1 more source
Synthetic and theoretical studies of novel ring closure and ring opening reactions [PDF]
, 2006 Ring closure and ring opening reactions are in many cases useful synthetic procedures in organic chemistry. They allow the preparation of complex molecules with high stereoselectivity and good yields. Mechanistic and theoretical studies have been carried
González Rosende, Mª Eugenia +1 more
core +1 more source
A comparative analysis of virucidal efficiency of biocide agents
Вопросы вирусологии, 2017 The main groups of biocide agents used for inactivation of bacteria and viruses were studied for their virucidal activity against enveloped (HIV, viral hepatitis C, influenza virus A) and non-enveloped viruses (poliovirus, adenovirus).
N. N. Nosik, D. N. Nosik, A. I. Chizhov
doaj +1 more source
“ Thioureidopeptide”: Novel Synthon for the Synthesis of N, N′, N″-Trisubstituted Guanidinopeptide Mimics [PDF]
, 2016 The synthesis of N α-protected N,N′,N″-trisubstituted guanidinopeptide mimic molecules suitably decorated in peptide backbone has been delineated in one pot employing HgCl2 as a desulphurizing agent.
Girish Prabhu, . +4 more
core +1 more source
Uraemic toxins and new methods to control their accumulation : game changers for the concept of dialysis adequacy [PDF]
, 2015 The current concept of an adequate dialysis based only on the dialysis process itself is rather limited. We now have considerable knowledge of uraemic toxicity and improved tools for limiting uraemic toxin accumulation. It is time to make use of these. A
Glorieux, Griet, Tattersall, James
core +2 more sources
Poly(dimethylsiloxane)-poly(ethyleneoxide)-heparin block copolymers. I. Synthesis and characterization [PDF]
, 1988 Amphiphilic block copolymers containing poly(dimethylsiloxane), poly(ethylene oxide), and heparin (PDMS-PEO-Hep) have been prepared via a series of coupling reactions using functionalized prepolymers, diisocyanates, and derivatized heparins.
Agarwal +40 more
core +10 more sources
Molecules, 2020 Galega officinalis L. has been known for centuries as an herbal medicine used to alleviate the symptoms of diabetes, but its comprehensive chemical composition and pharmacological activity are still insufficiently known.
Katarzyna Bednarska +2 more
doaj +1 more source
Structural and mechanistic insights into s-block bimetallic catalysis : sodium magnesiate-catalyzed guanylation of amines [PDF]
, 2016 To advance the catalytic applications of s-block mixed-metal complexes, sodium magnesiate [NaMg(CH2SiMe3)3] (1) is reported as an efficient precatalyst for the guanylation of a variety of anilines and secondary amines with carbodiimides.
Alonso-Moreno +109 more
core +1 more source
Nature Communications, 2021 So far, only a few chemical oscillators based on organic reactions have been developed. Here, the authors report both autocatalytic and oscillatory reaction networks that form substituted guanidines from thiouronium salts; when coupled to cascade ...
Alexander I. Novichkov +5 more
doaj +1 more source