Results 21 to 30 of about 4,664 (240)
Design and synthesis of a photoswitchable guanidine catalyst
Beilstein Journal of Organic Chemistry, 2012 A novel design as well as a straight-forward synthesis for a photoswitchable guanidine catalyst is reported. Intense studies of the photochromic properties demonstrated the reversible switchability of its photosensitive azobenzene moiety. Its activity in
Philipp Viehmann, Stefan Hecht
doaj +1 more source
One-pot synthesis of dihydropyrimidines via eco-friendly phosphorus derivatives catalysis
Journal of Saudi Chemical Society, 2022 A straightforward, cost effective and eco-friendly protocol for the Biginelli reaction relying on the use of readily available hypophosphorous acid is presented.
Zakaria Moutaoukil +2 more
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MoleculesLeishmaniasis remains an important neglected tropical disease, and current treatments are limited by toxicity, resistance, and low bioavailability. In this study, novel guanidine derivatives were evaluated through an integrated approach, combining in ...
Geovane Dias-Lopes +8 more
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Chemical and Pharmaceutical Bulletin, 2010 Guanidines are categorized as strong organobases; however, their catalytic utility in organic synthesis has not been discussed thoroughly. The author's group has extensively and systematically studied their potential ability focusing on: 1) modified guanidines as chiral auxiliaries; 2) guanidinium ylides for aziridine formation; 3) the affinity of ...
openaire +3 more sources
Beilstein Journal of Organic Chemistry, 2017 Depending on the reaction conditions, N,N’,N’’-tris(benzylamino)guanidinium salts can react with carboxylic acid chlorides to form either symmetrical N,N’,N’’-tris(N-acyl-N-benzylamido)guanidines 6 or mesoionic 4-amino-1,2,4-triazolium-3-hydrazinides 7 ...
Jan Szabo, Julian Greiner, Gerhard Maas
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Norbornane-based antibacterial agents: Benzyl and benzoyl substituted guanidines
European Journal of Medicinal Chemistry Reports, 2022 There is a pressing need to develop new antibiotics to replace those rendered ineffective as a result of widespread antimicrobial resistance. Naturally occurring cationic antimicrobial peptides (CAMPs) exhibit broad-spectrum antibacterial activity and ...
Gareth E. Boer +3 more
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Molecules, 2021 This paper reports the synthesis of branched alkylene guanidines using microfluidic technologies. We describe the preparation of guanidine derivatives at lower temperatures, and with significantly less time than that required in the previously applicable
Denis O. Shatalov +10 more
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecules, 2017 The synthesis and the evaluation as organocatalysts of new chiral guanidines derived from benzimidazoles in the enantioselective α-amination of 1,3-dicarbonyl compounds using di-t-butylazodicarboxylate as aminating agent is herein disclosed.
Llorenç Benavent +3 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source