Ring Finger Protein 1, a Novel Ubiquitin E3 Ligase Targeting Cancerous Inhibitor of Protein Phosphatase 2A to Suppress Smoking‐Induced Lung Tumorigenesis [PDF]
MedCommCancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein that promotes cancer cell proliferation, invasion, and drug resistance. In this study, CIP2A expression was found to be higher in lung cancer tissues compared to adjacent normal ...
In‐ho Jeong +4 more
doaj +3 more sources
CIP2A expression predicts recurrences of tamoxifen-treated breast cancer [PDF]
Tumor Biology, 2017 CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance.
Shawn Baldacchino +8 more
doaj +9 more sources
CIP2A expression is increased in prostate cancer [PDF]
Journal of Experimental & Clinical Cancer Research, 2010 Background The CIP2A protein is a recently characterized oncoprotein which inhibits protein phosphatase 2A activity. Expression of CIP2A has been detected in several carcinomas, but its expression and significance in prostate cancer has not been examined
Ristimäki Ari +2 more
doaj +8 more sources
ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. [PDF]
PLoS ONE, 2011 EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly
Anchit Khanna +6 more
doaj +6 more sources
CIP2A mediates mitotic recruitment of SLX4/MUS81/XPF to resolve replication stress-induced DNA lesions [PDF]
Nature CommunicationsPerturbed DNA replication can lead to incompletely replicated DNA when cells enter mitosis and can interfere with chromosome segregation. Cells therefore require mechanisms to resolve these lesions during mitosis. The CIP2A-TOPBP1 complex is described to
Lauren de Haan +14 more
doaj +2 more sources
The Emerging Role of the Cancerous Inhibitor of Protein Phosphatase 2A in Pulmonary Diseases [PDF]
MedicinaPromising protein targets are observed to play a role in multiple pathways across a variety of diseases, such as the regulation of immune responses, cell cycle, senescence, and DNA repair.
Hamza Hamza +7 more
doaj +2 more sources
Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer [PDF]
Scientific ReportsOvarian cancer (OvCa) is the sixth most common gynaecological cancer in the UK, accounting for over 200,000 deaths worldwide. Cancerous Inhibitor of Phosphatase 2 A (CIP2A) is an oncoprotein and an endogenous inhibitor of PP2A.
Alice Filipe +12 more
doaj +2 more sources
CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice. [PDF]
PLoS ONE, 2012 Protein phosphatase 2A (PP2A) is a critical regulator of protein serine/threonine phosphorylation. However, the physiological and developmental roles of different PP2A complexes are very poorly understood.
Sami Ventelä +9 more
doaj +6 more sources
CIP2A promotes inflammation and exacerbates osteoarthritis by targeting CEMIP [PDF]
Cellular & Molecular Biology LettersBackground Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degeneration with unclear pathogenic mechanism. This study aims to discuss the regulatory role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in OA ...
Jingyue Su +8 more
doaj +2 more sources
Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer. [PDF]
PLoS ONE, 2011 BackgroundLung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies.
Liang Ma +11 more
doaj +4 more sources