Results 101 to 110 of about 2,780 (190)
Mapping the Interaction Between LRRC59 and CIP2A Oncoprotein [PDF]
, 2017 The oncogene cancerous inhibitor of protein phosphatase 2A (CIP2A) has been shown to promote oncogenesis through numerous protein-protein interactions. CIP2A was initially found to be a direct inhibitor of the PP2A tumor suppressor protein; however, new ...
Reed, Tamika C.
core +1 more source
A reversible phospho-switch mediated by ULK1 regulates the activity of autophagy protease ATG4B [PDF]
, 2017 Upon induction of autophagy, the ubiquitin-like protein LC3 is conjugated to phosphatidylethanolamine (PE) on the inner and outer membrane of autophagosomes to allow cargo selection and autophagosome formation.
Agrotis, A +4 more
core +1 more source
Endoplasmic reticulum stress in diseases
MedComm, Volume 5, Issue 9, September 2024.The endoplasmic reticulum (ER) serves as a vital organelle in eukaryotic cells, performing essential roles such as protein folding, modification, and trafficking, lipid biosynthesis, and calcium regulation. Various conditions may disrupt ER function, potentially leading to the accumulation of unfolded and misfolded proteins, and triggering ER stress ...
Yingying Liu +5 more
wiley +1 more source
Kielisyöpä - varhainen toteaminen parantaa ennustetta [PDF]
, 2016 English ...
Atula, Timo +3 more
core
Cell Reports, 2015 An understanding of the mechanisms determining MYC’s transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting.
Kevin Myant +15 more
doaj +1 more source
Yumurtalık Kanseri Hücre Soylarında CIP2A Onkogeni Mutasyonlarının Taranması
Akdeniz Medical Journal, 2018 Amaç: Kanserle ilişkili genetik değişimlerin belirlenmesi erken tanı, hastalığın takibi ve hedefe yöneliktedavi yaklaşımlarının geliştirilmesi açısından önem taşımaktadır. CIP2A, birçok insan kanserleri ileilişkilendirilmiş yeni tanımlanmış bir onkoproteindir.
YAŞAR ŞİRİN, Duygu, BİLGEN, Türker
openaire +3 more sources
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
丙泊酚调控miRNA-383-5p/CIP2A的癌性抑制因子轴抑制膀胱癌细胞恶性进展
Zhongguo shiyan zhenduanxue, 2023 目的 探讨丙泊酚对膀胱癌细胞迁移及侵袭的影响以及其与微小RNA-383-5p(miR-383-5p)/蛋白磷酸酶2A的癌性抑制因子(CIP2A)轴的关系。方法 体外培养膀胱癌细胞，分别用0、5、10和20μg/mL丙泊酚进行处理，筛选出丙泊酚的最佳浓度，将膀胱癌细胞分为对照组、丙泊酚组、丙泊酚+miR-NC组、丙泊酚+miR-383-5p组、丙泊酚+si-con组、丙泊酚+si-CIP2A组、丙泊酚+miR-383-5p+pcDNA组和丙泊酚+miR-383-5p+pc-CIP2A组。CCK ...
王刚, 朱洪宽, 陈永伦, 李建钢
doaj
HapMap-based study of CIP2A gene polymorphisms and HCC susceptibility
Oncology Letters, 2012 CIP2A is a human oncoprotein that inhibits PP2A and stabilizes c-myc in human malignancies. Autoantibodies to CIP2A protein have been reported to be present in higher levels in sera from patients with hepatocellular carcinoma (HCC) than in sera of healthy individuals. The CIP2A gene has been demonstrated as a potential cancer susceptibility gene.
Yuchun, Li +8 more
openaire +3 more sources
A cytomegalovirus peptide-specific antibody alters natural killer cell homeostasis and ss shared in several autoimmune diseases [PDF]
, 2016 Human cytomegalovirus (hCMV), a ubiquitous beta-herpesvirus, has been associated with several autoimmune diseases. However, the direct role of hCMV in inducing autoimmune disorders remains unclear.
Dong, Jie +14 more
core +1 more source