Results 111 to 120 of about 2,780 (190)
Marine Drugs, 2015 Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified.
Ion Cristóbal +8 more
doaj +1 more source
MiR-218 as a multifunctional regulator of oncogenic processes in different solid tumors [PDF]
, 2016 MicroRNAs are highly conserved small non-coding regulatory RNAs that involve in post transcriptional regulating of gene expression during different cellular mechanisms.
Ahmadinejad, Fereshteh. +4 more
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CIP2A coordinates phosphosignaling, mitosis, and the DNA damage response
Trends in CancerHuman cancers share requirements for phosphorylation-dependent signaling, mitotic hyperactivity, and survival after DNA damage. The oncoprotein CIP2A (cancerous inhibitor of PP2A) can coordinate all these cancer cell characteristics. In addition to controlling cancer cell phosphoproteomes via inhibition of protein phosphatase PP2A, CIP2A directly ...
Srikar Nagelli, Jukka Westermarck
openaire +2 more sources
Molecules, 2019 Non-small cell lung cancer (NSCLC) patients carrying an epidermal growth factor receptor (EGFR) mutation are initially sensitive to EGFR-tyrosine kinase inhibitors (TKIs) treatment, but soon develop an acquired resistance.
Pengfei Liu +11 more
doaj +1 more source
CIP2A Immunosensor Comprised of Vertically-aligned Carbon Nanotube Interdigitated Electrodes Towards Point-of-Care Oral Cancer Screening [PDF]
, 2018 Vertically aligned carbon nanotube array (VANTA) coatings have recently garnered much attention due in part to their unique material properties including light absorption, chemical inertness, and electrical conductivity. Herein we report the first use of
Brownlee, Benjamin +10 more
core +2 more sources
Analysis of the Regulation and Function of CIP2A to Identify Candidate Biomarkers for Prostate Cancer [PDF]
, 2014 Protein Phosphatase 2A (PP2A) is a tumor suppressor involved in the regulation of several signaling pathways and the cell cycle. PP2A becomes inactivated by several inhibitors, including Cancerous Inhibitor of PP2A (CIP2A).
Savoly, Diana
core +1 more source
The effect of folic acid (FA) on breast cancer (BC) risk is uncertain. We hypothesised that this uncertainty may be due, in part, to differential effects of FA between BC cells with different phenotypes.
Burdge, Graham C. +2 more
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Identification and characterization of CIP2A as a novel oncogenic inhibitor of PP2A [PDF]
, 2012 Inhibition of the tumor suppressor protein phosphatase 2A (PP2A) activity has been identified as one of the five key alterations required for human cell transformation.
Niemelä, Minna
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