Results 171 to 180 of about 2,780 (190)

Sensitive Detection of Oral Leukoplakia: Analyzing P90 Biomarkers in Saliva and Tissue. [PDF]

Biosensors (Basel)
Wan HH, Zhu H, Chiang CC, Li JS, Ren F, Tsai CT, Liao YT, Neal D, Katz J, Esquivel-Upshaw JF.   +9 more
europepmc   +1 more source

Altering phosphorylation in cancer through PP2A modifiers. [PDF]

Cancer Cell Int
Johnson H, Narayan S, Sharma AK.
europepmc   +1 more source

Perspectives on the Application of Biosensors for the Early Detection of Oral Cancer. [PDF]

Sensors (Basel)
Nagdeve SN, Suganthan B, Ramasamy RP.
europepmc   +1 more source

Oncogene Silencing via ecDNA Micronucleation

Brückner L, Xu R, Tang J, Herrmann A, Wong IT, Zhang S, Tu F, Pilon M, Kukalev A, Pardon K, Sidorova O, Atta J, Yu Q, Pradella D, Ilić M, Novais-Cruz M, Kaltenbach S, Treue D, Giurgiu M, Herzog S, Hollinger A, Fernandez M, Becker F, Louma V, Schmargon R, Dörr J, Gamlin D, Lehmann A, Gürgen D, Richter M, Dubois F, Simeoni F, Pennycook BR, Hamilton A, Lindemann RK, Fischer M, Bafna V, Wahl G, Koche RP, Chang HY, Papathanasiou S, Medema R, Spanjaard B, Ventura A, Pombo A, Huang W, Werner B, Mischel PS, Henssen AG.   +48 more
europepmc   +1 more source

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CIP2A expression is elevated in cervical cancer

Cancer Biomarkers, 2011
Early detection of cervical cancer is critical for a favorable prognosis. Standard cytological detection methods, such as Pap smear, are highly subjective and HPV detection is not a reliable marker for predicting the malignancy potential of cervical lesions.
Lisa P, Huang, Martin E, Adelson, Eli, Mordechai, Jason P, Trama   +3 more
openaire   +2 more sources

CIP2A is overexpressed in esophageal squamous cell carcinoma

Medical Oncology, 2010
A human oncoprotein-designed cancerous inhibitor of PP2A (CIP2A) has been recently identified, which can stabilize c-Myc protein by inhibiting its degradation mediated by protein phosphatase 2A (PP2A) in tumor cells and promote the proliferation of various cancer cells.
Wei, Qu, Wenjuan, Li, Ling, Wei, Ligang, Xing, Xingwu, Wang, Jinming, Yu   +5 more
openaire   +2 more sources

CIP2A and TOPBP1: Molecular lassos that herd pulverized micronuclear chromosomes

Molecular Cell, 2023
Lin et al.1 demonstrate that acentric chromosome fragments generated within micronuclei are tethered by the CIP2A-TOPBP1 complex during mitosis, thus promoting clustered segregation of the fragments to a single daughter cell nucleus and facilitating re-ligation with limited chromosomal scattering and loss.
Chaithanya P, Vedula, Neil J, Ganem
openaire   +2 more sources

Clinical implications of CIP2A protein expression in breast cancer

Medical Oncology, 2013
The aim of this work is to study the expression and regulatory effects of CIP2A protein in breast cancer and the correlation between CIP2A protein expression and the prognosis of breast cancer. The CIP2A protein level was detected by immunohistochemistry staining.
Guangzhe, Yu, Guohong, Liu, Juan, Dong, Yingyu, Jin   +3 more
openaire   +2 more sources

p90/CIP2A mediates breast cancer cell proliferation and apoptosis

Molecular Biology Reports, 2014
Cancerous inhibitor of PP2A (p90/CIP2A) was recently characterized as an innovative oncoprotein in human malignancies. p90/CIP2A inhibited c-Myc-associated PP2A phosphatase activity to promote cell proliferation and tumor growth. A growing number of studies have demonstrated that the overexpression of p90/CIP2A in various human malignancies.
Xinxin, Liu, Bo, Peng, Yang, Li, Ningjing, Lei, Wenjie, Li, Jian-Ying, Zhang   +5 more
openaire   +2 more sources

Expression and prognostic significance of CIP2A in cutaneous malignant melanoma

Biomarkers, 2013
We investigated the expression and clinical significance of Cancerous inhibitor of protein phosphatase 2A (CIP2A) in Cutaneous malignant melanoma (CMM).CIP2A expression was analyzed by immunohistochemistry and western blot. We tested the invasion and migration capability of A375 cells with Matrigel invasion assay, Scratch migration assay and Matrigel ...
Feng, Shi, Yayun, Ding, Shaoqing, Ju, Xinhua, Wu, Shuanglin, Cao   +4 more
openaire   +2 more sources