Results 11 to 20 of about 2,780 (190)

The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis [PDF]

Nature Communications, 2022
In this work, CIP2A is discovered as a TOPBP1-interacting protein that regulates TOPBP1 localization specifically in mitosis. Cells lacking CIP2A display increased radio-sensitivity, micronuclei formation and chromosomal instability.
Mara De Marco Zompit, Mònica Torres Esteban, Clémence Mooser, Salomé Adam, Silvia Emma Rossi, Alain Jeanrenaud, Pia-Amata Leimbacher, Daniel Fink, Ann-Marie K. Shorrocks, Andrew N. Blackford, Daniel Durocher, Manuel Stucki   +11 more
doaj   +6 more sources

Penfluridol inhibits melanoma growth and metastasis through enhancing von Hippel‒Lindau tumor suppressor‐mediated cancerous inhibitor of protein phosphatase 2A (CIP2A) degradation [PDF]

MedComm
Melanoma's high metastatic potential, especially to the brain, poses significant challenges to patient survival. The blood‒brain barrier (BBB) is a major obstacle to the effective treatment of melanoma brain metastases.
Fuyan Xu, Jiao Li, Min Ai, Tingting Zhang, Yue Ming, Cong Li, Wenchen Pu, Yang Yang, Zhang Li, Yucheng Qi, Xiaomin Xu, Qingxiang Sun, Zhu Yuan, Yong Xia, Yong Peng   +14 more
doaj   +3 more sources

CIP2A Constrains Th17 Differentiation by Modulating STAT3 Signaling [PDF]

iScience, 2020
Summary: Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A) is an oncogene and a potential cancer therapy target protein. Accordingly, a better understanding of the physiological function of CIP2A, especially in the context of immune cells, is a ...
Mohd Moin Khan, Ubaid Ullah, Meraj H. Khan, Lingjia Kong, Robert Moulder, Tommi Välikangas, Santosh Dilip Bhosale, Elina Komsi, Omid Rasool, Zhi Chen, Laura L. Elo, Jukka Westermarck, Riitta Lahesmaa   +12 more
doaj   +5 more sources

CIP2A overexpression in Taiwanese oral cancer patients

Cancer Management and Research, 2019
Bharath Kumar Velmurugan,1 Hsin-Kai Wang,2,3 Chia-Min Chung,4,5 Chien-Hsun Lee,6 Lan-Ru Huang,7 Kun-Tu Yeh,6,7* Shu-Hui Lin6,8*1Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam; 2Public Health Bureau, Tainan City ...
Velmurugan BK, Wang HK, Chung CM, Lee CH, Huang LR, Yeh KT, Lin SH   +6 more
doaj   +4 more sources

The CIP2A-TOPBP1 axis facilitates mitotic DNA repair via MiDAS and MMEJ [PDF]

Nature Communications
Mitotic DNA double-strand breaks (DSBs) accumulate in response to replication stress or BRCA1/2 deficiency posing a significant threat to genome stability as repair by non-homologous end-joining (NHEJ) and homologous recombination (HR) is largely ...
Peter R. Martin, Jadwiga Nieminuszczy, Zuza Kozik, Nihal Jakub, Szymon Kowalski, Maxime Lecot, Julia Vorhauser, Karen A. Lane, Alexandra Kanellou, Jörg Mansfeld, Laurence H. Pearl, Antony W. Oliver, Jessica A. Downs, Jyoti S. Choudhary, Matthew Day, Wojciech Niedzwiedz   +15 more
doaj   +2 more sources

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer [PDF]

Cell Discovery
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lung.
Li-Jun Liang, Fu-Ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang, Bei-Bei Sun, Yu-Tao Liu, Gui-Zhen Wang, Guang-Biao Zhou   +9 more
doaj   +2 more sources

The Role of an Oncoprotein CIP2A in Breast Cancer [PDF]

, 2013
Cancerous inhibitor of PP2A (CIP2A) is an oncoprotein expressed in several human cancer types. Previously, CIP2A has been shown to promote proliferation of cancer cells. Mechanistically, CIP2A is known to inhibit activity of a tumor suppressor protein
Laine, Anni
core   +2 more sources

Reciprocal regulation of CIP2A and AR expression in prostate cancer cells

Discover Oncology, 2022
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an oncoprotein overexpressed in human malignancies, including prostate cancer (PCa). In this study, we aimed to explore the oncogenic function of CIP2A in PCa cells and its underlying mechanism. We
Hao-Wen Chuang, Jian-Hua Pan, Yi-Xuan Cai, Darius Rupa, Ting-Syuan Huang, Tzu-Chien Kuo, Chiao-Wen Lin, Chi-Wei Chen, Chia-Chin Lin, Herng-Sheng Lee, Ta-Chun Yuan   +10 more
doaj   +1 more source

Protein phosphatase 2A as a therapeutic target in acute myeloid leukemia [PDF]

, 2016
Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Adachi, Agarwal, Al-Murrani, Arnaud, Arnold, Barragan, Blalock, Blalock, Bononi, Bryan, Calin, Cancer Genome Atlas Research Network, Canela, Cervoni, Chen, Chen, Chen, Cheng, Christensen, Ciccone, Cohen, Come, Cristobal, Cristobal, Cristobal, Cristobal, Cristobal, Dohner, Dong, Eichhorn, Esplin, Estella-Hermoso de Mendoza, Fan, Gallay, Gao, Grallert, Haesen, Ingwersen, Irie, Janghorban, Janssens, Jin, Junttila, Kalla, Kalousi, Kandilci, Kelly, Khanna, Khanna, Kuo, Kutney, Lambrecht, Letourneux, Leulliot, Li, Liu, Longin, Low, Lucas, Lucas, Luo, Ma, Marcucci, Margolis, Mumby, Naetar, Neviani, Neviani, Neviani, Niemela, Oaks, Ofran, Perot, Perrotti, Perrotti, Pippa, Price, Ramaswamy, Roberts, Rorick, Rowe, Ruediger, Ruediger, Ruvolo, Ruvolo, Ruvolo, Ruvolo, Sablina, Sablina, Saddoughi, Saito, Schonthal, Seeling, Seo, Seshacharyulu, Seval, Shah, Shouse, Shouse, Switzer, ten Klooster, Trotta, Trotta, Turowski, Vasudevan, Wang, Wang, Wang, Westermarck, Wong, Xu, Xue, Yan, Yang, Yang, Yohe, Yu, Zwaenepoel   +117 more
core   +5 more sources

Downregulation of CIP2A inhibits cancer cell proliferation and vascularization in renal clear cell carcinoma

Biomedical Papers, 2020
Background: CIP2A has been proved to play a role as an oncogene in various types of malignancies while its functionality in renal clear cell carcinoma has not been investigated.
Hui Gao, Yuqiao Li, Tao Lin, Yan Cheng, Yunbo Ma   +4 more
doaj   +1 more source