Results 51 to 60 of about 129 (87)

Maximizing Efficacy of Cancer Nanovaccines and Immune Cells Landscape in Responders and Non‐Responders to Immunotherapy

Advanced Science, Volume 12, Issue 35, September 18, 2025.
To maximize the efficacy of cancer vaccines, adjuvants, collection, lysis, purification, oxidation, loading sites, and sizes, etc., are investigated. The optimized cancer nanovaccines loading whole tumor antigens can cure all or most tumor‐bearing mice in multiple mouse cancer models.
Xiangxiang Xu, Lu Diao, Jin Wang, Ao Zhu, Xianlan Chen, Yan Zheng, Yuhan Liu, Kang Hu, Jiashan Zhu, Cheng Ding, Chang Li, Yunzhi Pan, Jun Zhao, Mi Liu   +13 more
wiley   +1 more source

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Emerging roles of the cancerous inhibitor of protein phosphatase 2A (CIP2A) in ovarian cancer

Scientific Reports
Ovarian cancer (OvCa) is the sixth most common gynaecological cancer in the UK, accounting for over 200,000 deaths worldwide. Cancerous Inhibitor of Phosphatase 2 A (CIP2A) is an oncoprotein and an endogenous inhibitor of PP2A.
Alice Filipe, Sayeh Saravi, Denis Mustafov, Suzana Panfilov, Simran Banger, Seyedehnajmeh Mousavikivaj, Maria Braoudaki, Senthilkumar Kailasam, Yasser Riazalhosseini, Michelle A. Sahai, Fotios Drenos, Cristina Sisu, Emmanouil Karteris   +12 more
doaj   +1 more source

Prenatal Characterization of Houge–Janssens Syndrome Type 2: A Case Report and Systematic Review of Fetal Phenotypes Associated With PPP2R1A Mutations

Molecular Genetics &Genomic Medicine, Volume 13, Issue 8, August 2025.
We present the most comprehensive synthesis to date of prenatal phenotypes associated with PPP2R1A‐related neurodevelopmental disorders. Ventriculomegaly, callosal anomalies, and heart defects are key prenatal indicators, supporting early diagnosis and informed genetic counseling.
Jiancheng Hu, Jialun Pang, Lin Zhou, Haiyan Kuang, Wenxian Yu, Ying Peng   +5 more
wiley   +1 more source

Cucurbitacin B induces inhibitory effects via the CIP2A/PP2A/C-KIT signaling axis in t(8;21) acute myeloid leukemia

Journal of Pharmacological Sciences, 2019
Acute myeloid leukemia (AML) is the most common subtype of hematological malignancy in humans, and its incidence increases with age. The treatment of AML still faces challenges.
Wenjing Ma, Yuchen Xiang, Rui Yang, Te Zhang, Jiaxin Xu, Yezi Wu, Xuewen Liu, Ke Xiang, Huzi Zhao, Ying Liu, Yuan Si   +10 more
doaj   +1 more source

Upregulation of CIP2A in estrogen depletion‐resistant breast cancer cells treated with low‐dose everolimus

FEBS Open Bio, 2020
Everolimus (EVE), an inhibitor of mammalian target of rapamycin, is an emerging second‐line therapeutic option for hormone therapy‐resistant breast cancers.
Eiji Nishio, Takanori Hayashi, Mao Akaza, Yukiko Hisatomi, Masahiro Hikichi, Takuma Fujii, Toshiaki Utsumi, Nobuhiro Harada, Yohei Shimono   +8 more
doaj   +1 more source

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation

Cell Reports, 2015
An understanding of the mechanisms determining MYC’s transcriptional and proliferation-promoting activities in vivo could facilitate approaches for MYC targeting.
Kevin Myant, Xi Qiao, Tuuli Halonen, Christophe Come, Anni Laine, Mahnaz Janghorban, Johanna I. Partanen, John Cassidy, Erinn-Lee Ogg, Patrizia Cammareri, Tiina Laiterä, Juha Okkeri, Juha Klefström, Rosalie C. Sears, Owen J. Sansom, Jukka Westermarck   +15 more
doaj   +1 more source

丙泊酚调控miRNA-383-5p/CIP2A的癌性抑制因子轴抑制膀胱癌细胞恶性进展

Zhongguo shiyan zhenduanxue, 2023
目的 探讨丙泊酚对膀胱癌细胞迁移及侵袭的影响以及其与微小RNA-383-5p(miR-383-5p)/蛋白磷酸酶2A的癌性抑制因子(CIP2A)轴的关系。方法 体外培养膀胱癌细胞，分别用0、5、10和20μg/mL丙泊酚进行处理，筛选出丙泊酚的最佳浓度，将膀胱癌细胞分为对照组、丙泊酚组、丙泊酚+miR-NC组、丙泊酚+miR-383-5p组、丙泊酚+si-con组、丙泊酚+si-CIP2A组、丙泊酚+miR-383-5p+pcDNA组和丙泊酚+miR-383-5p+pc-CIP2A组。CCK ...
王刚, 朱洪宽, 陈永伦, 李建钢
doaj  

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Cell Discovery
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lung.
Li-Jun Liang, Fu-Ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang, Bei-Bei Sun, Yu-Tao Liu, Gui-Zhen Wang, Guang-Biao Zhou   +9 more
doaj   +1 more source

CIP2A recruits SLX4-MUS81-XPF in mitosis and protects against replication stress

EMBO Reports
DNA replication stress can generate mitotic defects because incompletely replicated chromosomes or unresolved replication intermediates tether sister chromatids and hinder their segregation.
Alice Meroni, Annica Pellizzari, Nathalie Varisco, Francesco Leone, Giada Greco, Andrea Hänel, Pascale Brasier-Lutz, Isabell Witzel, Alessandro A Sartori, Manuel Stucki   +9 more
doaj   +1 more source