Results 81 to 90 of about 2,780 (190)

CIP2A oncoprotein controls cell growth and autophagy through mTORC1 activation [PDF]

Journal of Cell Biology, 2014
mTORC1 (mammalian target of rapamycin complex 1) integrates information regarding availability of nutrients and energy to coordinate protein synthesis and autophagy. Using ribonucleic acid interference screens for autophagy-regulating phosphatases in human breast cancer cells, we identify CIP2A (cancerous inhibitor of PP2A [protein phosphatase 2A]) as ...
Puustinen, Pietri, Rytter, Anna, Mortensen, Monika, Kohonen, Pekka, Moreira, José M., Jäättelä, Marja   +5 more
openaire   +2 more sources

Harnessing Noncanonical Proteins for Next‐Generation Drug Discovery and Diagnosis

WIREs Mechanisms of Disease, Volume 17, Issue 3, May/June 2025.
Noncanonical proteins: Emerging players in human health and disease. This figure illustrates the discovery, characterization, and functional significance of noncanonical proteins across various biological processes and disease states, highlighting their potential as novel therapeutic targets and biomarkers for personalized medicine approaches ...
Nachiket Rajinikanth, Ruchi Chauhan, Sudhakaran Prabakaran   +2 more
wiley   +1 more source

CIP2A regulates proliferation and apoptosis of multiple myeloma cells

Molecular Medicine Reports, 2016
Multiple myeloma (MM) is one of the most common causes of mortality from hematological malignancy in China. Recent studies have demonstrated that cancerous inhibitor of protein phosphatase 2A (CIP2A) may exhibit a role in promoting the growth of cancer; however, the function of CIP2A in MM remains unknown.
Zhuanzhen, Zheng, Zhenhua, Qiao, Wenliang, Chen, Rong, Gong, Yalin, Wang, Lianrong, Xu, Yanping, Ma, Li, Zhang, Yujin, Lu, Bo, Jiang, Guoxia, Li, Chunxia, Dong   +11 more
openaire   +3 more sources

Expression of CIP2A and CD44v6 in condyloma acuminatum-involved skin and its correlation with patients' prognosis

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the expression levels of cancerous inhibitor of protein phosphatase 2A (CIP2A) and CD44v6 in condyloma acuminatum (CA)-involved skin and to analyze the correlation between their expression and the distribution of HPV genotypes in
ZHANG Yijie, YANG Can, LIN Yongli
doaj   +1 more source

Endoplasmic Reticulum Stress: Triggers Microenvironmental Regulation and Drives Tumor Evolution

Cancer Medicine, Volume 14, Issue 5, March 2025.
ABSTRACT Background The endoplasmic reticulum (ER) serves as a crucial hub for protein synthesis and processing, playing an essential role in maintaining protein homeostasis. Perturbations, such as hypoxia, oxidative stress, inadequate amino acid supply, Ca2+ imbalance, and acidosis, can disrupt cellular equilibrium and result in the accumulation of ...
Chaosheng Peng, Juan Wang, Shu Wang, Yan Zhao, Haoyuan Wang, Yuhao Wang, Yuxuan Ma, Jianjun Yang   +7 more
wiley   +1 more source

HDAC1 controls CIP2A transcription in human colorectal cancer cells

Oncotarget, 2016
This work describes the effectiveness of HDAC-inhibitor (S)-2 towards colorectal cancer (CRC) HCT116 cells in vitro by inducing cell cycle arrest and apoptosis, and in vivo by contrasting tumour growth in mice xenografts. Among the multifaceted drug-induced events described herein, an interesting link has emerged between the oncoprotein histone ...
BALLIU, MANJOLA, CELLAI, CRISTINA, LULLI, MATTEO, LAURENZANA, ANNA, TORRE, EUGENIO, VANNUCCHI, ALESSANDRO MARIA, PAOLETTI, FRANCESCO   +6 more
openaire   +3 more sources

Celastrol inhibits chondrosarcoma proliferation, migration and invasion through suppression CIP2A/c-MYC signaling pathway

Journal of Pharmacological Sciences, 2017
Chondrosarcomas (CS) is the second most frequent tumors of cartilage origin. A small compound extracted from Thunder God Vine (Tripterygium wilfordii Hook.
Jinhui Wu, Muchen Ding, Ningfang Mao, Yungang Wu, Chao Wang, Jiabin Yuan, Xiong Miao, Jingfeng Li, Zhicai Shi   +8 more
doaj   +1 more source

METTL16 is Required for Meiotic Sex Chromosome Inactivation and DSB Formation and Recombination during Male Meiosis

Advanced Science, Volume 12, Issue 3, January 20, 2025.
METTL16 predominantly controls the expression of critical meiotic genes essential for DSB formation and recombination in early meiotic spermatocytes and is involved in the expansion of DNA damage response (DDR) factors and epigenetic modifications in the XY body for the establishment and maintenance of meiotic sex chromosome inactivation (MSCI) in ...
Lisha Yin, Nan Jiang, Wenjing Xiong, Shiyu Yang, Jin Zhang, Mengneng Xiong, Kuan Liu, Yuting Zhang, Xinxin Xiong, Yiqian Gui, Huihui Gao, Tao Li, Yi Li, Xiaoli Wang, Youzhi Zhang, Fengli Wang, Shuiqiao Yuan   +16 more
wiley   +1 more source

Bortezomib Congeners Induce Apoptosis of Hepatocellular Carcinoma via CIP2A Inhibition

Molecules, 2013
CIP2A is an oncoprotein that upregulates p-Akt and promotes cancer cell proliferation and survival. The proteasome inhibitor bortezomib has been shown to reduce CIP2A and lead to cell apoptosis.
Duen-Ren Hou, Ann-Chi Huang, Chung-Wai Shiau, Chun-Yi Wang, Hui-Chuan Yu, Kuen-Feng Chen   +5 more
doaj   +1 more source

Quantitative Proteomics Analysis of Differentially Expressed Proteins in Serum of Former Uranium Miners by Isobaric Tags for the Relative and Absolute Quantitation

Dose-Response, 2021
The carcinogenicity of radon has been convincingly documented through epidemiological studies of underground miners. However, there is a lack of early warning indicators for radon radiation damage.
Xuhong Dang, Haipeng Lin, Yayi Yuan, Biao Yang, Juancong Dong, Zhongxin Zhang, Kai Yang, Youchen Li, Xiaozhen Li, Dongliang Chai, Yahui Zuo   +10 more
doaj   +1 more source