Advanced 3D Documentation and Capacity Building for Post-Conflict Damage Assessment: The Case of the Taras Shevchenko Chernihiv Regional Academic Music and Drama Theatre, Ukraine [PDF]
This paper presents the methodologies and findings from of a technical mission undertaken to document and assess the Taras Shevchenko Chernihiv Regional Academic Music and Drama Theatre in Chernihiv, Ukraine — an emblematic cultural landmark within
M. Skamantzari +3 more
doaj +1 more source
Background Viral infections have a history of abrupt and severe eruptions through the years in the form of pandemics. And yet, definitive therapies or preventive measures are not present. Herbal medicines have been a source of various antiviral compounds
Madiha Haider +15 more
doaj +1 more source
Adipocyte-specific ablation of plakoglobin in mice does not affect adiposity but results in sexual-dimorphic effects on weight gain. [PDF]
Abstract The main transcriptional coactivator of the WNT pathway, β‐catenin, is a well‐established regulator of adipogenesis and fat expansion, but our knowledge of how other members of the catenin family participate in adipogenesis remains incomplete. Previous studies have elucidated a role for the β‐catenin homolog, plakoglobin, in the regulation of ...
Abou Azar F +6 more
europepmc +2 more sources
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias [PDF]
Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) hold promise for assessment of drug-induced arrhythmias and are being considered for use under the comprehensive in vitro proarrhythmia assay (CiPA).
Blinova, Ksenia +17 more
core +1 more source
En Europa occidental, la democracia social responde a una serie de condiciones históricas y políticas que no se encuentran en la América Latina de los años 20. Por otro lado, las políticas liberales aplicadas en la región produjeron una destacada heterogeneidad en las fuerzas laborales y una profundización de las desigualdades sociales que volvían muy ...
openaire +2 more sources
Comprehensive in vitro Proarrhythmia Assay (CiPA): Pending issues for successful validation and implementation [PDF]
International audienceIntroduction: The Comprehensive in vitro Proarrhythmia Assay (CiPA) is a nonclinical Safety Pharmacology paradigm for discovering electrophysiological mechanisms that are likely to confer proarrhythmic liability to drug candidates ...
Ballet, Veronique +5 more
core +4 more sources
Analysis of pathogenic variants and prenatal genetic diagnosis in families with congenital insensitivity to pain with anhidrosis [PDF]
Objective Genetic testing and prenatal diagnosis were conducted in 18 congenital insensitivity to pain with anhidrosis(CIPA)families, laying the foundation for reducing the incidence of CIPA.
CHEN Xin, LI Shuang, JIANG Yulin, REN Xiuzhi, ZHAO Xiuli
doaj +1 more source
Secretion and assembly of functional mini-cellulosomes from synthetic chromosomal operons in Clostridium acetobutylicum ATCC 824. [PDF]
Background: Consolidated bioprocessing (CBP) is reliant on the simultaneous enzyme production, saccharification of biomass, and fermentation of released sugars into valuable products such as butanol. Clostridial species that produce butanol are, however,
Bolam, DN +7 more
core +1 more source
Investigation of a Novel NTRK1 Variation Causing Congenital Insensitivity to Pain With Anhidrosis
Background: Congenital insensitivity to pain with anhidrosis (CIPA), a rare autosomal recessive sensory neuropathy, was caused mainly by biallelic mutations in the NTRK1 gene.
Kai Yang +10 more
doaj +1 more source
One Law with Two Outcomes: Comparing the Implementation of CIPA in Public Libraries and Schools
Though the Children’s Internet Protection Act (CIPA) established requirements for both public libraries and public schools to adopt filters on all of their computers when they receive certain federal funding, it has not attracted a great amount of ...
Paul T. Jaeger, Zheng Yan
doaj +1 more source

