Results 141 to 150 of about 133,735 (361)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Features of Structural Hardware Transformation of Information in Cryptosystems

open access: yesДоклады Белорусского государственного университета информатики и радиоэлектроники
The article considers types, functions and some features of cryptosystems, as well as circuit design options for expanding their functionality. Options for generating keys and ciphers used in cryptosystems with a typical structural organization, and ...
A. F. Chernyavskiy   +2 more
doaj   +1 more source

Length-Doubling Ciphers and Tweakable Ciphers [PDF]

open access: yes, 2012
We motivate and describe a mode of operation HEM (resp., THEM) that turns a n-bit blockcipher into a variable-input-length cipher (resp., tweakable cipher) that acts on strings of [n..2n−1] bits. Both HEM and THEM are simple and intuitive and use only two blockcipher calls, while prior work at least takes three.
openaire   +1 more source

Linear Cryptanalysis Method for DES Cipher

open access: yesInternational Conference on the Theory and Application of Cryptographic Techniques, 1994
M. Matsui
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

About the Soviet Cryptographs’ Contribution to the Great Patriotic War Victory

open access: yesБезопасность информационных технологий, 2015
This article deals with the unknown facts of the soviet cryptograph activity during the Great Patriotic War. The specialists of our Cryptographic Service were able to provide the secret connection between the political and military members of the ...
Dmitry Aleksandrovich Larin
doaj  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Enciphering on the basis of the sums with products of weight and free components as summands

open access: yesVestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2012
The purpose of the given paper is reviewing of mathematical resources of enciphering of the source text, allowing to ensure the simplicity of appropriate decryption; the source text is a sequence of integer weight coefficients. The composer of the cipher
Alexander I Nikonov
doaj  

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