Results 211 to 220 of about 91,976 (334)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

LWLCM: A novel lightweight stream cipher using logistic chaos function and multiplexer for IoT communications. [PDF]

PLoS One
Afzal S, Bokhari MU, Alam M, Husain MS, Khan MZ, Ashraf Z.   +5 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Low burden of clinically relevant anaemia and thrombocytopenia among adolescents living with HIV receiving tenofovir/lamivudine plus dolutegravir: the CIPHER-ADOLA study in Cameroon. [PDF]

AIDS Res Ther
Fainguem NN, Bouba Y, Kamgaing R, Gabisa JE, Ka'e AC, Tchouaket MCT, Nka AD, Ayafor C, Forgwei L, Kamgaing N, Tetang SN, Ateba FN, Takou D, Tameza DG, Noukayo F, Ketchaji A, Jagni Semengue EN, Roland WB, Agabus W, Gnambi AR, Eyenga C, Etame NK, Kengni Ngueko AM, Moko Fotso LG, Yimga JF, Zam KN, Motaze AN, Chenwi CA, Beloumou GA, Djupsa Njdeyep SC, Roy U, Ajeh RA, Njom Nlend AE, Koki PN, Tchidjou HK, Armenia D, Santoro MM, Ceccherini-Silberstein F, Sosso SM, Ndjolo A, Colizzi V, Perno CF, Fokam J.   +42 more
europepmc   +1 more source

Imperceptible and Robust Encryption: Salsa20 Stream Cipher for Colour Image Data

Aldi Azmi Arfian, Christy Atika Sari, Eko Hari Rachmawanto, Folasade Olubusola Isinkaye   +3 more
openalex   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Digital image encryption utilizing high-dimensional cellular neural networks and lower-upper triangular decomposition of matrix. [PDF]

Sci Prog
Tao L, Liang X, Han L, Hu B.
europepmc   +1 more source

MILP/MIQCP‐Based Fully Automatic Method of Searching for Differential‐Linear Distinguishers for SIMON‐Like Ciphers [PDF]

Yanyan Zhou, Senpeng Wang, Bin Hu
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

RGB image encryption using SPN with a novel block cipher over simple graph adjacency matrices and Galois fields. [PDF]

Sci Rep
Sajjad M, Alqwaifly NA.
europepmc   +1 more source