Results 71 to 80 of about 87,772 (336)

BREAKING LITTLEWOOD'S CIPHER

Cryptologia, 2004
In 1953, the celebrated mathematician John Edensor Littlewood proposed a stream cipher based on logarithm tables. Fifty years later, we propose the first analysis of his scheme. Littlewood suggests the idea of using real functions as tools to build cryptographic primitives.
openaire   +4 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Quantum Noise Randomized Ciphers

, 2006
We review the notion of a classical random cipher and its advantages. We sharpen the usual description of random ciphers to a particular mathematical characterization suggested by the salient feature responsible for their increased security.
C. Helstrom, C. Shannon, Ch. G. Gunther, D. R. Stinson, Eric Corndorf, H. N. Jendahl, H. P. Yuen, Horace P. Yuen, Lo, Prem Kumar, Ranjith Nair, T. M. Cover, Takami Eguchi, V. Chepyzhov   +13 more
core   +1 more source

Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation

FEBS Letters, EarlyView.
The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen, Zenon Toprakcioglu, Michele Vendruscolo   +2 more
wiley   +1 more source

KRIPTOGRAFI DENGAN KOMPOSISI CAESAR CIPHER DAN AFFINE CIPHER UNTUK MENGUBAH PESAN RAHASIA [PDF]

, 2016
Kriptografi caesar cipher dan affine cipher adalah kriptografi yang sederhana dan mudah dipecahkan. Salah satu cara agar pesan menjadi sulit dipecahkan yaitu dengan cara mengkomposisi kedua cipher tersebut. Komposisi kriptografi caesar cipher dan affine
Wijaya, Muhammad Lutfi
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Implementing Knowledge Translation Strategies in Funded Research in Canada and Australia: A Case Study

Technology Innovation Management Review, 2016
There is an emerging literature describing the use of knowledge translation strategies to increase the relevance and usability of research, yet there are few real-world examples of how this works in practice. This case study reports on the steps taken to
Gabriel Moore, Therese Fitzpatrick, Ivy Lim-Carter, Abby Haynes, Anna Flego, Barbara Snelgrove   +5 more
doaj  

Efektivitas Pesan Teks Dengan Cipher Substitusi, Vigenere Cipher, dan Cipher Transposisi

Majalah Ilmiah Teknologi Elektro, 2018
Penelitian ini bertujuan untuk mengetahui efektivitas suatu keamanan pesan berbasis teks dengan metode kriptografi klasik seperti Substitusi, Vigenere, dan Transposisi. Dengan penerapan metode kriptografi, diharapkan mampu untuk meminimalisasi terjadinya penyadapan terhadap pesan teks.
Nyoman Putra Sastra, M. Azman Maricar
openaire   +4 more sources

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source