Results 41 to 50 of about 102,682 (307)

Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression

Molecular Cancer, 2018
Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH. However, the role of circ-ITCH in bladder cancer (BCa)
Chengdi Yang, Wenbo Yuan, X. Yang, Peng Li, Jingzi Wang, Jie Han, J. Tao, Pengchao Li, Haiwei Yang, Q. Lv, Wei Zhang   +10 more
semanticscholar   +1 more source

Exosomal circ‐0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axis

Clinical and Translational Medicine
Background Breast cancer (BC) is one of the most prevalent malignant tumours that threatens women health worldwide. It has been reported that circular RNAs (circRNAs) play an important role in regulating tumour progression and tumour microenvironment ...
Minyu Zhuang, Xiao-Qin Zhang, Jie Ji, Hongfei Zhang, Li Shen, Yanhui Zhu, Xiaoan Liu   +6 more
semanticscholar   +1 more source

Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis

Cell Death and Disease, 2022
Numerous studies have shown that circRNAs are aberrantly expressed in various cancers and play a significant role in tumor progression. However, the molecular mechanisms of circRNAs in triple-negative breast cancer (TNBC) remain ambiguous.
Zekun Wang, Yaming Li, Jingwen Yang, Yiran Liang, Xiaolong Wang, Ning Zhang, Xiaoli Kong, Bing Chen, Lijuan Wang, Wenjing Zhao, Qifeng Yang   +10 more
semanticscholar   +1 more source

Dissolved organic matter regulates nutrient limitation and growth of benthic algae in northern lakes through interacting effects on nutrient and light availability

Limnology and Oceanography Letters, 2020
Widespread increases in dissolved organic matter (DOM) concentration across northern lakes can alter rates of primary production by increasing nutrient availability and decreasing light availability.
Megan L. Fork, Jan Karlsson, Ryan A. Sponseller   +2 more
doaj   +1 more source

CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer

BMC Gastroenterology, 2022
Background CircRNA circ-ATAD1 has been characterized as an oncogenic circRNA in gastric cancer, while its role in colorectal cancer (CRC) is unknown. This study was carried out to explore the role of circ-ATAD1 in CRC. Methods Paired CRC and adjacent non-
Li Cao, Guanglong Dong, Huan Li
doaj   +1 more source

Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU

Theranostics
Background: Knowledge about the pathogenesis of depression and treatments for this disease are lacking. Epigenetics-related circRNAs are likely involved in the mechanism of depression and have great potential as treatment targets, but their mechanism of ...
Yujie Cai, Yao-dong Ji, Yingxuan Liu, Dandan Zhang, Z. Gong, Li Li, Xiongjin Chen, Chunmei Liang, Sifan Feng, Jiongtong Lu, Qinjie Qiu, Zhixiong Lin, Yan Wang, Lili Cui   +13 more
semanticscholar   +1 more source

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas

Cell Death and Disease, 2022
Autophagy is an evolutionally conserved catabolic process that degrades cells to maintain homeostasis. Cisplatin-activated autophagy promotes the expression of circ-PKD2, which plays a role as a tumor suppressor gene in the proliferation, migration, and ...
Ling Gao, Qian Zhang, Shaoming Li, Jingjing Zheng, W. Ren, K. Zhi   +5 more
semanticscholar   +1 more source

Hypoxia induced exosomal Circ-ZNF609 promotes pre-metastatic niche formation and cancer progression via miR-150-5p/VEGFA and HuR/ZO-1 axes in esophageal squamous cell carcinoma

Cell Death Discovery
Exosomes derived from cancer are regarded as significant mediators of cancer-host crosstalk. Hypoxia, on the other hand, is one of the essential characteristics of solid tumors.
Yu Mao, Jiahao Wang, Yimin Wang, Z. Fu, Li-xin Dong, Jia Liu   +5 more
semanticscholar   +1 more source

Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma

Molecular Therapy: Nucleic Acids, 2022
Intrahepatic cholangiocarcinoma (ICC) is a liver tumor featured by challenges of non-invasive early diagnosis and a higher prevalence rate in Asian countries. These characteristics necessitate the development of liquid biopsy and immunotherapy methods to
Xuezhu Wang, Guanqun Wang, Zilong Wu, Yucheng Dong, Yue Shi, F. Yang, Xinyue Chen, Jun Wang, S. Du, Haifeng Xu, Yongchang Zheng   +10 more
semanticscholar   +1 more source

Exosomal circ-0020887 and circ-0009590 as novel biomarkers for the diagnosis and prediction of short-term adverse cardiovascular outcomes in STEMI patients

Open Medicine, 2023
This study attempted to identify exosomal circular RNAs (circRNAs) as diagnostic and prognostic biomarkers for patients with ST-segment elevation myocardial infarction (STEMI).
Wang Guan, Wang Chun, Huang Zhengyi, Sun Shuai, Chen Yanjun   +4 more
doaj   +1 more source