Results 111 to 120 of about 153,020 (377)

MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]

, 2016
FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M, Dole, Neha S, Franceschetti, Tiziana, Hrdlicka, Henry C, Smith, Spenser S   +4 more
core   +1 more source

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

The Anatomical Record, EarlyView.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek, Feyzullah Beyaz, Mustafa Öztop, Harun Karaca, Ahmet Cabir, Begüm Fatma Kiryar   +5 more
wiley   +1 more source

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Sleep, Health, and Aging [PDF]

, 2003
As people grow older, getting a good night's sleep remains essential to maintaining good health. Insomnia is a common complaint in older adults, and although occasional sleep complaints may not be associated with age, chronic sleep difficulties are ...
Judith Estrine, Nora O'Brien
core  

Functional regression with intensively measured longitudinal outcomes: a new lens through data partitioning

Canadian Journal of Statistics, EarlyView.
Abstract Modern longitudinal data from wearable devices consist of biological signals at high‐frequency time points. Distributed statistical methods have emerged as a powerful tool to overcome the computational burden of estimation and inference with large data, but methodology for distributed functional regression remains limited.
Cole Manschot, Emily C. Hector
wiley   +1 more source

Sleep Disorders and Genes [PDF]

, 2019
Versão preprintThe sleep-wake cycle is a neurobiological phenomenon that shows intervals of activity alternating with restfulness that appears with a periodicity approximating the 24h day-night cycle.
Amici, Amin, Ban, Barbagallo, Basheer, Borbely, Brando, Brower, Byrne, Cade, Cade, Carskadon, Chaki, Chang, Chase, Chatterjee, Chen, Cohen, Cohen, Dall’Ara, de Lima, Dement, Dijk, Dong, Evans, Franco-Tormo, Fuh, Gan-Or, Gillombardo, Gottesmann, Gottesmann, Guilleminault, Han, Hennessy, Hirotsu, Hobson, Hobson, Hu, Huang, Huang, Jinek, Johansson, Keenan, Khan, Li, Lin, Lind, Luo, Lusk, Mahowald, Mendlewicz, Mistlberger, Miyagawa, Monti, Murillo-Rodríguez, Naiman, Nir, Nishino, Nordgren, Ollila, Pace-Schott, Palagini, Panda, Pandi-Perumal, Parish, Parmeggiani, Parsons, Patel, Peirano, Petit, Posner, Potter, Rechtschaffen, Riddle, Rizzo, Roffwarg, Scammell, Scherer, Serretti, Serretti, Shalem, Siclari, Siegel, Spada, Subramani, Szentkirályi, Tafti, Torterolo, Torterolo, Torterolo, Torterolo, Torterolo, Toth, Toyoda, Truong, Turek, Utge, van Maanen, Videnovic, Von Economo, Wu, Yong   +101 more
core   +1 more source

A Joint Pharmacometric Model of Iohexol and Creatinine Administered through a Meat Meal to Assess GFR and Renal OCT2/MATE Activity

Clinical Pharmacology &Therapeutics, EarlyView.
Accurately assessing glomerular filtration rate (GFR) from plasma creatinine concentrations is challenging in patients with unstable renal function. This study aimed to refine the understanding of creatinine kinetics for more reliable assessments of GFR and net creatinine tubular secretion (nCTS) via OCT2/MATE in humans.
Zhendong Chen, Qian Dong, Charalambos Dokos, Jana Boland, Uwe Fuhr, Max Taubert   +5 more
wiley   +1 more source

Diagnóstico dos transtornos do sono relacionados ao ritmo circadiano Diagnosis of circadian rhythm sleep disorders

Jornal Brasileiro de Pneumologia, 2008
Queixas de insônia e sonolência excessiva são comuns na investigação dos distúrbios respiratórios do sono; os transtornos do sono relacionados ao ritmo circadiano talvez sejam as causas mais freqüentemente esquecidas no diagnóstico diferencial destes ...
Denis Martinez, Maria do Carmo Sfreddo Lenz, Luiz Menna-Barreto   +2 more
doaj   +1 more source

The development and course of bipolar spectrum disorders: an integrated reward and circadian rhythm dysregulation model.

Annual Review of Clinical Psychology, 2015
In this article, we present and review the evidence for two major biopsychosocial theories of the onset and course of bipolar spectrum disorders (BSDs) that integrate behavioral, environmental, and neurobiological mechanisms: the reward hypersensitivity ...
L. Alloy, R. Nusslock, Elaine M Boland
semanticscholar   +1 more source

Integrating Artificial Intelligence and Smartphone Technology to Enhance Personalized Assessment and Treatment for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Smartphone technology presents a promising path toward expanding access to evidence‐based eating disorder assessment and treatment. Despite rapid technological advances, research has yet to harness these systems in ways that make personalized digital health care a clinical reality.
Jake Linardon, John Torous
wiley   +1 more source