Results 41 to 50 of about 153,020 (377)
Frontiers in Physiology, 2020 Alzheimer’s disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1).
Youli Yao +9 more
doaj +1 more source
Solving the mystery of human sleep schedules one mutation at a time. [PDF]
, 2013 Sleep behavior remains one of the most enigmatic areas of life. The unanswered questions range from "why do we sleep?" to "how we can improve sleep in today's society?" Identification of mutations responsible for altered circadian regulation of human ...
Fu, Ying-Hui +2 more
core +1 more source
Circadian rhythms in obsessive–compulsive disorder [PDF]
Journal of Neural Transmission, 2012 The etiopathology and neurobiology of obsessive-compulsive disorder (OCD) are not fully understood. As for altered circadian rhythms associated with OCD, hormonal dysregulation and a delayed sleep phase have come into the focus of research. The novel antidepressant agomelatine is able to resynchronize circadian rhythms and the augmentative ...
Oliver Tucha +5 more
openaire +4 more sources
The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice [PDF]
, 2013 Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong to the super family of G-protein-coupled receptors consisting of the typical seven transmembrane domains.
De Berardis D. +10 more
core +2 more sources
Chronobiology and Mood Disorders [PDF]
Psikiyatride Güncel Yaklaşımlar, 2011 Living organizms show cyclic rhythmicity in a variety of physiological, hormonal, behavioral, and psychological processes. Sleep-wake cycles, body temperature, hormone levels, mood and cognition display a circadian rhythm in humans.
Yavuz Selvi +2 more
doaj
Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease. [PDF]
, 2018 Huntington's disease (HD) patients suffer from a progressive neurodegeneration that results in cognitive, psychiatric, cardiovascular, and motor dysfunction.
Colwell, Christopher S +5 more
core +1 more source
Advances in the Study of Circadian Genes in Non-Small Cell Lung Cancer
Integrative Cancer Therapies, 2022 Circadian genes regulate several physiological functions such as circadian rhythm and metabolism and participate in the cytogenesis and progression of various malignancies.
Hao Zhang MMed +4 more
doaj +1 more source
Circadian rhythm and neurodegenerative disorders [PDF]
Brain Science Advances, 2020 The circadian clock controls daily rhythms in animal physiology, metabolism, and behavior, such as the sleep‐wake cycle. Disruption of circadian rhythms has been revealed in many diseases including neurodegenerative disorders. Interestingly, patients with many neurodegenerative diseases often show problems with circadian clocks even years before other
Michelle Werdann, Yong Zhang
openaire +2 more sources
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal [PDF]
, 2006 Every physiological function in the human body exhibits some form of circadian rhythmicity. Under pathological conditions, however, circadian rhythmicity may be dusrupted.
Ding, Jian M. +9 more
core +3 more sources
Recent advances in modulators of circadian rhythms: an update and perspective
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Circadian rhythm is a universal life phenomenon that plays an important role in maintaining the multiple physiological functions and regulating the adaptability to internal and external environments of flora and fauna.
Shenzhen Huang +5 more
doaj +1 more source