Results 71 to 80 of about 153,020 (377)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Research advances in the study of sleep disorders, circadian rhythm disturbances and Alzheimer’s disease

Frontiers in Aging Neuroscience, 2022
Although there are still no satisfactory answers to the question of why we need to sleep, a better understanding of its function will help to improve societal attitudes toward sleep. Sleep disorders are very common in neurodegenerative diseases and are a
Xiangyang Xiong, Tianpeng Hu, Zhenyu Yin, Yaodan Zhang, Fanglian Chen, Ping Lei   +5 more
doaj   +1 more source

Dual‐Selective Terahertz‐Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations

Advanced Materials, EarlyView.
Observation and detection of neurotransmitter dynamics in aqueous system has been hurdle for analytical fields due to its weak and reversible nature. A terahertz‐nanodisc metasurface which implements comprehensive detection over conformational change and selective sensing is introduced. Utilizing the THz regime photonics and biomimetic environment with
Taeyeon Kim, Yeon Kyung Lee, Yeeun Roh, Jaehun Park, Yong‐Sang Ryu, Hyun Seok Song, Minah Seo   +6 more
wiley   +1 more source

Circadian cycle and neuroinflammation

Open Life Sciences, 2023
Circadian cycle is a fundamental characteristic of life formed in the long-term evolution of organisms and plays an important role in maintaining the proliferation, migration, and activation of immune cells.
Xu Xinzi, Wang Junli, Chen Guohua
doaj   +1 more source

Comparative Review of Approved Melatonin Agonists for the Treatment of Circadian Rhythm Sleep‐Wake Disorders

Pharmacotherapy, 2016
Circadian rhythm sleep‐wake disorders (CRSWDs) are characterized by persistent or recurrent patterns of sleep disturbance related primarily to alterations of the circadian rhythm system or the misalignment between the endogenous circadian rhythm and ...
Wilbur P. Williams, D. McLin, M. Dressman, D. Neubauer   +3 more
semanticscholar   +1 more source

Non-24-Hour Sleep-Wake Disorder Revisited – A Case Study [PDF]

, 2016
The human sleep-wake cycle is governed by two major factors: a homeostatic hourglass process (process S), which rises linearly during the day, and a circadian process C, which determines the timing of sleep in a ~24-h rhythm in accordance to the external
Bromundt, Vivien, Brunner, Daniel P., Cajochen, Christian, Eckert, Anne, Garbazza, Corrado, Hackethal, Sandra, Meier, Fides   +6 more
core   +3 more sources

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Adaptive mechanisms of homeostasis disorders

Journal of Education, Health and Sport, 2017
The ability to preserve a permanent level of internal environment in a human organism, against internal and external factors, which could breach the consistency, can be define as homeostasis.
Anna Maria Dobosiewicz, Daria Braun, Kamila Kromrych, Hubert Puszcz, Kalina Ziółkowska, Maja Kozłowska   +5 more
doaj   +3 more sources

Bright Light Therapy in Parkinson's Disease: An Overview of the Background and Evidence

Parkinson's Disease, 2012
Sleep disorders are common in Parkinson's disease (PD) and seem to be strongly associated with depression. It has been suggested that sleep disorders as well as depression are caused by a disturbed circadian rhythm.
Sonja Rutten, Chris Vriend, Odile A. van den Heuvel, Jan H. Smit, Henk W. Berendse, Ysbrand D. van der Werf   +5 more
doaj   +1 more source

Circadian Rhythm Dysregulation and Restoration: The Role of Melatonin

Nutrients, 2021
Sleep is an essential component of overall human health but is so tightly regulated that when disrupted can cause or worsen certain ailments. An important part of this process is the presence of the well-known hormone, melatonin. This compound assists in
Clayton Vasey, Jennifer McBride, K. Penta   +2 more
semanticscholar   +1 more source