Results 71 to 80 of about 1,747,809 (284)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Jixie chuandong, 2004 According to the characteristic of non-circle gear pitch line and method of calculation, all kind of non-circle gear pitch can be express by the uniform formula using subsection cubic spline, only the discrete points in the pitch of non-circle gear are ...
李建刚 +3 more
doaj
A Hybrid of Darboux's Method and Singularity Analysis in Combinatorial Asymptotics [PDF]
, 2006 A ``hybrid method'', dedicated to asymptotic coefficient extraction in combinatorial generating functions, is presented, which combines Darboux's method and singularity analysis theory.
Flajolet, Philippe +4 more
core +5 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2020 In this paper, we propose the active noise control method for the same phase sources distributed on the circle. These sources, which have zero lobe mode, is radiate from the duct fan without attenuation in the duct.
Tatsuhiko GOTO, Akihiko ENAMITO
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Advances in Mechanical Engineering, 2013 The inspection of pipe inside is very important so as to ensure the safety of pipe transmission. The pipe defect detection method based on inside 3D points acquired by circle structured light vision system was discussed in this paper.
Wang Ying, Jin Cuiyun, Zhang Yanhui
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
We count integral quaternion zeros of $\gamma_1^2 \pm \dots \pm \gamma_n^2$, giving an asymptotic when $n\ge 9$, and a likely near-optimal bound when $n=8$. To do so, we introduce a new, nonabelian delta symbol method, which is of independent interest.
Arala, Nuno +5 more
openaire +2 more sources