Results 41 to 50 of about 646,489 (284)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Simulation Analysis for Opening Performance of Medium Voltage Vacuum Circuit Breaker Based on ADAMS and Maxwell

MATEC Web of Conferences, 2017
The circuit breakers play a important role in control and protect the power systemand the vacuum circuit breaker has beenwidely used in the field of medium voltage with its excellent opening performance.Virtual prototyping technology is alsobecamemore ...
Ding Xianliang, Wang Zhiming, Yin Qinlin, Chen Pengwei, Zhou Shijin, Yang Yang   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Control Circuit Optimization for High-speed Circuit Breaker in Traction System of Jinan Metro Line 3

Chengshi guidao jiaotong yanjiu
[Objective] In the early operation stage of Jinan Metro Line 3, multiple sporadic high-speed circuit breaker closing failures are reported. To improve the reliability of train operation, it is necessary to optimize the high-speed circuit breaker control ...
Xu ZHANG, Xianchao ZHAO, Yanna ZHAO
doaj   +1 more source

Modelamento de um minidisjuntor sob curto-circuito [PDF]

, 2005
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Este trabalho apresenta um modelo computacional de um minidisjuntor de maneira a simular o comportamento deste ...
Günther, Ivo Detlev
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

HVDC Circuit Breakers–A Review [PDF]

IEEE Access, 2020
HVDC circuit breakers are of increasing importance, as multi-terminal high voltage DC (HVDC) transmission becomes a commercial reality. Multiple HVDC breaker technologies have been developed, and are starting to appear as proof-of-concept installations on real networks. Information about them is however distributed widely in the literature.
Mike Barnes, Damian Sergio Vilchis-Rodriguez, Xiaoze Pei, Roger Shuttleworth, Oliver Cwikowski, Alexander C. Smith 0001   +5 more
openaire   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Design and Implementation of an Auto-Oriented Bidirectional ZCS Hybrid Circuit Breaker

IEEE Access, 2021
To protect power systems from severe short circuit faults, the zero-current switching (ZCS) technique is widely accepted due to its fast interruption speed.
Zhuangxian Jiang, Chao Guo, Chengjin Ye, Yi Ding, Xueyong Tang, Youtong Fang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source