Results 101 to 110 of about 5,709,499 (335)

Sudden change of constraints in selected suspended structures

open access: yesMATEC Web of Conferences, 2018
In the paper the problem of analytic mechanics, concerning sudden change of constrains is analysed. Four rigid bodies suspended by two oblique ropes in the gravitational field are considered: the beam, the rectangular shield, the triangular shield and ...
Szcześniak Wacław, Ataman Magdalena
doaj   +1 more source

Origin of mesosiderites as a natural consequence of planet formation [PDF]

open access: yes
The mineral composition of mesosiderites is described and a theory of the origin and evolution of these meteorites is presented. It is suggested that the asteroid parent body of the mesosiderites also formed in the inner solar system, perhaps just within
Rubin, A. E., Wasson, J. T.
core   +1 more source

On the Uniqueness of Co-circular Four Body Central Configurations

open access: yesArchive for Rational Mechanics and Analysis, 2021
We study central configurations lying on a common circle in the Newtonian four-body problem. Using a topological argument we prove that there is at most one co-circular central configuration for each cyclic ordering of the masses on the circle.
openaire   +3 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Noncollision Periodic Solutions for Circular Restricted Planar Newtonian Four-Body Problems

open access: yesMathematics
We study a class of circular restricted planar Newtonian four-body problems in which three masses are positioned at the vertices of a Lagrange equilateral triangle configuration, each mass revolving around the center of mass in circular orbits.
Xiaoxiao Zhao, Liang Ding, Shiqing Zhang
doaj   +1 more source

The calculation of rotor/fuselage interaction for two-dimensional bodies [PDF]

open access: yes
Unsteady rotor wake interactions with the empennage, tail boom, and other aerodynamic surfaces have a significant influence on the aerodynamic performance of the helicopter, ride quality, and vibration.
Stremel, Paul M.
core   +1 more source

Improved approximate inspirals of test-bodies into Kerr black holes

open access: yes, 2005
We present an improved version of the approximate scheme for generating inspirals of test-bodies into a Kerr black hole recently developed by Glampedakis, Hughes and Kennefick.
C. W. Helstrom   +8 more
core   +1 more source

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