Results 91 to 100 of about 1,397,584 (286)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Occurrence and Characteristics of Serpula himantioides Fruiting Bodies on Living Trees in Japan

open access: yesJournal of Fungi
Serpula himantioides is a globally distributed wood decay fungus that causes heartwood decay in several tree species. We investigated the occurrence of S.
Ryusei Haraguchi   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Inviscid mean flow through and around groups of bodies [PDF]

open access: yes, 2004
General estimates are derived for mean velocities through and around groups or arrays of fixed and moving bodies, in unbounded and bounded domains, which lie within a defined perimeter.
Hunt, J. C. R.   +13 more
core   +2 more sources

On the restricted circular three-charged-body problem

open access: yesAstrophysics and Space Science, 1987
Three bodies \(M_ 1\), \(M_ 2\) and M with masses \(m_ 1\), \(m_ 2\) and \(m=0\), and charges \(q_ 1\), \(q_ 2\), \(q=0\) revolve around the centre of mass of the first two in circular orbits attracting (or repulsing) each other according to the Newtonian and Coulombian inverse square law.
Dionysiou, D.D., Vaiopoulos, D.A.
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Noncollision Periodic Solutions for Circular Restricted Planar Newtonian Four-Body Problems

open access: yesMathematics
We study a class of circular restricted planar Newtonian four-body problems in which three masses are positioned at the vertices of a Lagrange equilateral triangle configuration, each mass revolving around the center of mass in circular orbits.
Xiaoxiao Zhao, Liang Ding, Shiqing Zhang
doaj   +1 more source

Sudden change of constraints in selected suspended structures

open access: yesMATEC Web of Conferences, 2018
In the paper the problem of analytic mechanics, concerning sudden change of constrains is analysed. Four rigid bodies suspended by two oblique ropes in the gravitational field are considered: the beam, the rectangular shield, the triangular shield and ...
Szcześniak Wacław, Ataman Magdalena
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

Circular on Schedule of Submission of the 2023 Every Two-Year Declaration of Income. Assets and Liabilities Forms [PDF]

open access: yes, 2023
Reference is made to Circular Ref. No.PSC/218/110/XII VOL.Vll/(19) dated 18th October, 2023 providing guidelines for receiving and processing of the 2023 every two year declarations of income assets and liabilities forms by organizations. In this regard,
The Public Service Commission
core  

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