Results 71 to 80 of about 70,630 (259)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Occurrence and Characteristics of Serpula himantioides Fruiting Bodies on Living Trees in Japan

Journal of Fungi
Serpula himantioides is a globally distributed wood decay fungus that causes heartwood decay in several tree species. We investigated the occurrence of S.
Ryusei Haraguchi, Toshihide Hirao, Toshihiro Yamada   +2 more
doaj   +1 more source

Repair, reuse and job creation

Field Actions Science Reports, 2021
Fédération Envie comprises some fifty organizations employing 2,860 people, 2,011 of them on employment integration schemes, and generating approximately €81 million in turnover across France.
Jean-Paul Raillard
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Sudden change of constraints in selected suspended structures

MATEC Web of Conferences, 2018
In the paper the problem of analytic mechanics, concerning sudden change of constrains is analysed. Four rigid bodies suspended by two oblique ropes in the gravitational field are considered: the beam, the rectangular shield, the triangular shield and ...
Szcześniak Wacław, Ataman Magdalena
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On the restricted circular three-charged-body problem

Astrophysics and Space Science, 1987
Three bodies \(M_ 1\), \(M_ 2\) and M with masses \(m_ 1\), \(m_ 2\) and \(m=0\), and charges \(q_ 1\), \(q_ 2\), \(q=0\) revolve around the centre of mass of the first two in circular orbits attracting (or repulsing) each other according to the Newtonian and Coulombian inverse square law.
Dionysiou, D.D., Vaiopoulos, D.A.
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Collaborative networks for circularity

Global Sustainability
Non-technical summary Transitioning to a circular economy (CE) – where materials are reused rather than discarded – is a key sustainability challenge in Latin America and the Caribbean (LAC). Quality infrastructure (QI), encompassing standards, metrology,
Ulrich Harmes-Liedtke, Andrés Matta, Monica Muñoz, Evelyn Canelas   +3 more
doaj   +1 more source