Results 61 to 70 of about 77,352 (348)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of Damping and Reynolds Number on Vortex-Induced Vibrations [PDF]

open access: yes, 2007
Vortex-induced vibrations have been studied experimentally with emphasis on damping and Reynolds number effects. Our system was an elastically-mounted rigid circular cylinder, free to oscillate only transverse to the flow direction, with very low ...
Klamo, Joseph Thomas
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Dynamics of a high-Reynolds-number bubble rising within a thin gap [PDF]

open access: yes, 2012
We report an experimental analysis of path and shape oscillations of an air bubble of diameter d rising in water at high Reynolds number in a vertical Hele-Shaw cell of width h.
Billet, Anne-Marie   +3 more
core   +1 more source

Linear Polarization Variations and Circular Polarization Are Common among Airless Bodies

open access: yesThe Planetary Science Journal
Using the POLISH2 polarimeter at the Lick Observatory Shane 3 m and Nickel 1 m telescopes, we discover rotation-phase-locked variations in linear polarization to be common among asteroids and a near-Earth object (NEO) in a clear, 383−720 nm bandpass ...
Sloane J. Wiktorowicz   +2 more
doaj   +1 more source

Can We Create a Circular Pharmaceutical Supply Chain (CPSC) to Reduce Medicines Waste?

open access: yesPharmacy, 2020
Background: The increase in pharmaceutical waste medicines is a global phenomenon and financial burden. The Circular Economy, as a philosophy within the pharmaceutical supply chain, aims to promote waste reduction, maximise medicines value, and enable ...
Abdullah Alshemari   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Construction of Analytical Eigensolutions for Isotropic Conical Bodies and Their Application for Estimation of Stresses Singularity

open access: yesFracture and Structural Integrity, 2019
A complete set of eigensolutions is constructed for different variants of circular conical bodies: homogeneous cone with one lateral surface (solid cone), homogeneous cone with two lateral surfaces (hollow cone) and composite cone for different variants ...
Tatyana Korepanova   +2 more
doaj   +3 more sources

Własności Mechaniczne Kilku Modeli Gruntów

open access: yesEngineering Transactions, 1964
This paper is devoted to the description and analysis of some results concerning problems of granular bodies representing continuous bodies. The test have been performed by means of samples composed of parallel glass rods of circular or polygonal cross ...
J. Biarez
doaj  

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