Results 61 to 70 of about 270,881 (261)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Quantitative Analysis of Life-Cycle Embodied Carbon in Residential Buildings Under Different Design Patterns

Buildings
The building sector is a major source of global carbon emissions, with embodied carbon playing an increasingly critical role. This study quantitatively compares the life-cycle embodied carbon of three residential building design patterns (cast-in situ ...
Rihan Hai, Ruijie Du, Yu Shao, Limuge Che, Ruihong Yan, Quanyi Zheng, Yuling Chen, Mengxiao Jin   +7 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Promoting Circular Design in the Built Environment: Insights from the Application of Material Stock Analysis to a Case Study in Milan

Applied Sciences
The construction sector plays a central role in global resource depletion and waste generation, with construction and demolition activities accounting for more than one-third of total waste produced in the European Union.
Michele Versaci, Francesco Pittau, Iacopo Pizzutilo, Gabriele Masera   +3 more
doaj   +1 more source

Circular Design Research in The Netherlands

In 2023, the Netherlands is strategic partner of the Business of Design Week held in Hong Kong, with Circular Design as the central theme. One of the objectives of this partnership is to foster enduring international cooperation. As an initial step towards future collaborative efforts, the Network Applied Design Research (NADR) made an inventory of the
Hollander, M.C. den, Idema, Marijke, Joore, Peter   +2 more
openaire   +4 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Circular Design and Functionalized Upcycling of Waste Commodity Polystyrene via C-H Activation Using Microwave-Assisted Multicomponent Synthesis. [PDF]

Polymers (Basel), 2023
Shetranjiwalla S, Cislak C, Scotland KM.
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Going circular with what we wear and how we build: parallelisms between the Dutch and French catwalks of fashion and construction

Frontiers in Sustainability
Responding to the call for circular transition, the Dutch and French governments aspire to achieve a fully circular economy by developing a transitional agenda in various sectors, including fashion and construction. The two countries are among the top 10
Norman Dytianquin, Simon Paindavoine, Simon Paindavoine, Nikos Kalogeras, Nikos Kalogeras   +4 more
doaj   +1 more source

Circular Materials and Circular Design-Review on Challenges Towards Sustainable Manufacturing and Recycling. [PDF]

Circ Econ Sustain, 2022
Dumée LF.
europepmc   +1 more source