Results 171 to 180 of about 3,020,470 (372)

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Homochirality through Photon-Induced Melting of RNA/DNA: the Thermodynamic Dissipation Theory of the Origin of Life [PDF]

, 2010
The homochirality of the molecules of life has been a vexing problem with no generally accepted solution to date. Since a racemic mixture of chiral nucleotides frustrates the extension and replication of RNA and DNA, understanding the origin of ...
Karo Michaelian
core   +2 more sources

Topological entropy of a stiff ring polymer and its connection to DNA knots

, 2001
We discuss the entropy of a circular polymer under a topological constraint. We call it the {\it topological entropy} of the polymer, in short. A ring polymer does not change its topology (knot type) under any thermal fluctuations.
Brian A. A., Chen Y. D., de Gennes P. G., Dean F. B., Deguchi T., Deguchi T., Deguchi T., Deguchi T., Delbück M., des Cloizeaux J., Frisch H. L., Grosberg A., Grosberg A. Yu., Janse van Rensburg E. J., Klenin K. V., Koniaris K., Le Bret M., Madras N., Michels J. P. J., Odijk T., Orlandini E., Polyak M., Rybenkov V. V., Shaw S. Y., Shishido K., Stiger D., Vologodskii A. V., Walba D. M.   +27 more
core   +1 more source

Evidence for semiconservative replication of circular polyoma DNA. [PDF]

, 1966
Bernhard Hirt
openalex   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

Molecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche, Renske Imschoot, Béatrice Lintermans, Lode Denolf, Joachim Taminau, Charlotte Fieuws, Geert Berx, Kris Gevaert, Kathleen B. M. Claes   +8 more
wiley   +1 more source

Nucleosomal DNA has topological memory

Nature Communications
One elusive aspect of the chromosome architecture is how it constrains the DNA topology. Nucleosomes stabilise negative DNA supercoils by restraining a DNA linking number difference (∆Lk) of about −1.26.
Joana Segura, Ofelia Díaz-Ingelmo, Belén Martínez-García, Alba Ayats-Fraile, Christoforos Nikolaou, Joaquim Roca   +5 more
doaj   +1 more source

A DYE-BUOYANT-DENSITY METHOD FOR THE DETECTION AND ISOLATION OF CLOSED CIRCULAR DUPLEX DNA: THE CLOSED CIRCULAR DNA IN HELA CELLS [PDF]

, 1967

openalex   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Diverse circular single-stranded DNA viruses discovered from research greenhouses and agro-ecosystems [PDF]

, 2013
This study focuses on the diversity of circular single-stranded DNA (ssDNA) viruses associated with Poaceae growing in the fynbos ecosystem and its neighbouring agroecosystems in the Cape floristic region of Southern Africa.
Bernardo, Pauline, Fernandez, Emmanuel, Filloux, Denis, Fort, Guillaume, Galzi, Serge, Roumagnac, Philippe   +5 more
core  

Torsional Mechanics of Circular DNA

Circular DNA found in the cell is actively regulated to an underwound state, with their superhelical density close toσ∼ - 0.06. While this underwound state is essential to life, how it impacts the torsional mechanical properties of DNA is not fully understood.
Gundeep Singh, Yifeng Hong, James T. Inman, James P. Sethna, Michelle D. Wang   +4 more
openaire   +2 more sources