Results 11 to 20 of about 208,265 (305)

Detection and Validation of Circular DNA Fragments Using Nanopore Sequencing

Frontiers in Genetics, 2022
Occurrence of extra-chromosomal circular DNA is a phenomenon frequently observed in tumor cells, and the presence of such DNA has been recognized as a marker of adverse outcome across cancer types.
Alicia Isabell Tüns, Till Hartmann, Simon Magin, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Rocío Chamorro González, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Anton George Henssen, Sven Rahmann, Alexander Schramm, Johannes Köster   +15 more
doaj   +2 more sources

Differences in sequences between HBV-relaxed circular DNA and covalently closed circular DNA [PDF]

Emerging Microbes and Infections, 2017
The hepatitis B virus (HBV) genome exists in two forms: circular covalently closed DNA (cccDNA) and relaxed circular DNA (RCDNA). Here, we investigated the presence of differences in the sequences of both forms in paired samples of serum and liver tissue.
Magda Rybicka, Anna Woziwodzka, Tomasz Romanowski, Piotr Stalke, Marcin Dręczewski, Krzysztof Piotr Bielawski   +5 more
doaj   +4 more sources

The potential clinical implications of extrachromosomal circular DNA as a biomarker [PDF]

Genes and Diseases
Extrachromosomal circular DNA (eccDNA) is a class of circular DNA molecules that originate from and are independent of conventional chromosomes. The high specificity and stability of the circular structure of eccDNA provide new clues for its research as ...
Xuanmei Luo, Jian Cui, Hexin Li, Gang Zhao, Lihui Zou   +4 more
doaj   +2 more sources

Expression of HIV from a 1-LTR circular DNA in the absence of integration [PDF]

Retrovirology
Background Like all retroviruses, two kinds of viral DNA are present in the nucleus of HIV-infected cells: integrated DNA and a pool of unintegrated DNA containing linear and circular forms. For the most part, it has been difficult to examine the role of
Corrado Gurgo, Claudio Fenizia, Katherine McKinnon, Ru-ching Hsia, Genoveffa Franchini   +4 more
doaj   +2 more sources

Extrachromosomal Circular DNA and Transposable Elements in Type 2 Diabetes. [PDF]

Int J Mol Sci
Moya-Valera C, Arita AF, Lara-Hernández F, García-García AB, Chaves FJ.   +4 more
europepmc   +2 more sources

Dynamics of extrachromosomal circular DNA in rice [PDF]

Nature Communications
The genome’s dynamic nature, exemplified by elements like extrachromosomal circular DNA (eccDNA), is crucial for biodiversity and adaptation. Yet, the role of eccDNA in plants, particularly rice, remains underexplored.
Jundong Zhuang, Yaoxin Zhang, Congcong Zhou, Danlin Fan, Tao Huang, Qi Feng, Yiqi Lu, Yan Zhao, Qiang Zhao, Bin Han, Tingting Lu   +10 more
doaj   +2 more sources

The extrachromosomal circular DNA atlas of aged and young mouse brains [PDF]

Scientific Data
Extrachromosomal circular DNA (eccDNA) refers to a distinct class of circular DNA molecules that exist independently from linear chromosomal DNA. Extensive evidence has firmly established the significant involvement of eccDNA in cancer initiation ...
Xiaoning Hong, Jing Li, Peng Han, Shaofu Li, Jiaying Yu, Haoran Zhang, Jiang Li, Yonghui Dang, Xi Xiang   +8 more
doaj   +2 more sources

Comparative analysis of methodologies for detecting extrachromosomal circular DNA. [PDF]

Nat Commun
Gao X, Liu K, Luo S, Tang M, Liu N, Jiang C, Fang J, Li S, Hou Y, Guo C, Qu K.   +10 more
europepmc   +3 more sources

Transposable elements and circular DNAs [PDF]

Mobile Genetic Elements, 2016
Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs).
Tobias Mourier
openalex   +4 more sources

Molecular mechanisms of extrachromosomal circular DNA formation. [PDF]

Nucleic Acids Res
Eugen-Olsen RAB, Hariprakash JM, Oestergaard VH, Regenberg B.   +3 more
europepmc   +3 more sources