Results 51 to 60 of about 3,020,470 (372)

Unfolding of Nanoconfined Circular DNA [PDF]

Biophysical Journal, 2015
Nanofluidic channels have become a versatile tool to manipulate single DNA molecules. They allow investigation of confined single DNA molecules from a fundamental polymer physics perspective as well as for example in DNA barcoding techniques.Circular DNA is of interest since it is found in many biologically relevant contexts, such as bacterial plasmids,
Jonas O. Tegenfeldt, Tobias Ambjörnsson, Erik Werner, Charleston Noble, Fredrik Persson, Bernhard Mehlig, Joachim Fritzsche, Lena Nyberg, Mohammadreza Alizadehheidari, Fredrik Westerlund   +9 more
openaire   +2 more sources

Replicative aging is associated with loss of genetic heterogeneity from extrachromosomal circular DNA in Saccharomyces cerevisiae

bioRxiv, 2020
Circular DNA of chromosomal origin form from all parts of eukaryotic genomes. In yeast, circular rDNA accumulates as cells divide, contributing to replicative aging.
I. Prada-Luengo, Henrik D. Møller, R. Henriksen, Qian Gao, C. E. Larsen, Sefa Alizadeh, L. Maretty, J. Houseley, Birgitte Regenberg   +8 more
semanticscholar   +1 more source

Electron microscopic observation of mitochondrial DNA isolated from a human kidney: circular dimers in histologically normal organ mitochondria [PDF]

, 1971
Circular DNA isolated from human kidney mitochondria was studied by electron microscopy. I. Mean contour length of monomers of the mitochondrial DNA was 4.96 ± SE 0.28 /μ 2.
Hirata, Seiichi, Oda, Takuzo, Seki, Shuji   +2 more
core   +1 more source

Simulations of Knotting in Confined Circular DNA [PDF]

Biophysical Journal, 2008
The packing of DNA inside bacteriophages arguably yields the simplest example of genome organization in living organisms. As an assay of packing geometry, the DNA knot spectrum produced upon release of viral DNA from the P4 phage capsid has been analyzed, and compared to results of simulation of knots in confined volumes.
Micheletti, Cristian, MARENDUZZO D, ORLANDINI E, SUMNERS DW   +3 more
openaire   +5 more sources

Denaturation of circular DNA: Supercoils and overtwist [PDF]

Physical Review E, 2012
The denaturation transition of circular DNA is studied within a Poland-Scheraga type approach, generalized to account for the fact that the total linking number (LK), which measures the number of windings of one strand around the other, is conserved. In the model the LK conservation is maintained by invoking both overtwisting and writhing (supercoiling)
Bar, Amir, Kabakcioglu, Alkan, Mukamel, David   +2 more
openaire   +7 more sources

Discovery of several thousand highly diverse circular DNA viruses

bioRxiv, 2019
Although it is suspected that there are millions of distinct viral species, fewer than 9,000 are catalogued in GenBank’s RefSeq database. We selectively enriched for and amplified the genomes of circular DNA viruses in over 70 animal samples, ranging ...
Michael J. Tisza, D. Pastrana, N. Welch, Brittany N. Stewart, A. Peretti, G. Starrett, Y. Y. Pang, S. Krishnamurthy, P. Pesavento, David H. McDermott, P. Murphy, Jessica L. Whited, Bess M. Miller, J. Brenchley, Stephan P. Rosshart, B. Rehermann, J. Doorbar, Blake A. Ta’ala, O. Pletnikova, J. Troncoso, S. Resnick, B. Bolduc, Matthew B. Sullivan, A. Varsani, A. Segall, C. Buck   +25 more
semanticscholar   +1 more source

The adaptive potential of circular DNA accumulation in ageing cells

Current Genetics, 2020
Carefully maintained and precisely inherited chromosomal DNA provides long-term genetic stability, but eukaryotic cells facing environmental challenges can benefit from the accumulation of less stable DNA species.
R. Hull, J. Houseley
semanticscholar   +1 more source

Transposable elements and circular DNAs [PDF]

Mobile Genetic Elements, 2016
Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs).
openaire   +4 more sources

Synthetic metallomolecules as agents for the control of DNA structure [PDF]

, 2007
This tutorial review summarises B-DNA structure and metallomolecule binding modes and illustrates some DNA structures induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt amines, ruthenium octahedral metal complexes,
Adair D. Richards, Alessio, Alison Rodger, Baschnagel, Bierbach, Boulikas, Bragg, Brey, Browning, Carle, Chargaff, Clarke, Coggan, den Hartog, Eichhorn, Gale, Gessner, Goodsell, Guschlbauer, Hannon, Hannon, Haq, Hiort, Holliday, Humphrey, Khalid, Laine, Lerman, Lerman, Levitt, Liu, Loprete, Mainwaring, Manzotti, Marrington, Meistermann, Miescher, Molderheim, Neidle, Oleksi, Parkinson, Parkinson, Peberdy, Pelta, Rodger, Rodger, Rodger, Rodger, Rodger, Rosenberg, Sherman, Tabor, Ushay, Watson, Zou   +54 more
core   +1 more source

Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing

Nature Communications
Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide RNA sequences only minimally activate Cas12a ribonucleoproteins.
Fei Deng, Yi Li, Biyao Yang, Rui Sang, Wei Deng, Maya Kansara, Frank Lin, S. Thavaneswaran, David M. Thomas, Ewa M. Goldys   +9 more
semanticscholar   +1 more source