Results 71 to 80 of about 3,020,470 (372)
Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.
PLoS ONE, 2019 Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and ...
Fumihiko Takeuchi +16 more
doaj +1 more source
Helix untwisting and bubble formation in circular DNA [PDF]
, 2013 The base pair fluctuations and helix untwisting are examined for a circular molecule. A realistic mesoscopic model including twisting degrees of freedom and bending of the molecular axis is proposed.
Bates A. D. +3 more
core +2 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Evolution of a highly functional circular DNA aptamer in serum
Nucleic Acids Research, 2020 Circular DNA aptamers are powerful candidates for therapeutic applications given their dramatically enhanced biostability. Herein we report the first effort to evolve circular DNA aptamers that bind a human protein directly in serum, a complex biofluid ...
Yu Mao +9 more
semanticscholar +1 more source
Topoisomerase 2 is dispensable for the replication and segregation of small yeast artificial chromosomes (YACs). [PDF]
PLoS ONE, 2014 DNA topoisomerases are thought to play a critical role in transcription, replication and recombination as well as in the condensation and segregation of sister duplexes during cell division.
Jorge Cebrián +5 more
doaj +1 more source
Conformation of Circular DNA in 2 Dimensions
, 2008 The conformation of circular DNA molecules of various lengths adsorbed in a 2D conformation on a mica surface is studied. The results confirm the conjecture that the critical exponent $\nu$ is topologically invariant and equal to the SAW value (in the ...
A. D. Bates +5 more
core +1 more source
Mitochondrial DNA replication in sea urchin oocytes [PDF]
, 1974 Mitochondrial DNA (mtDNA) replicative intermediates from Strongylocentrotus purpuratus oocytes were isolated by ethidium bromide-CsCl density gradient centrifugation and examined by electron microscopy after formamide spreading.
Kasamatsu, Harumi +3 more
core +2 more sources
Circular DNA in Isolated Chromoplasts
Zeitschrift für Naturforschung C, 1974 Abstract Flower chromoplasts of Narcissus pseudonarcissus have been isolated in high purity and inte grity by a new procedure. From these chromoplasts circular DNA molecules in supercoiled form have been isolated and demonstrated by electron microscopy to have a contour length of about 44 μm (molecular weight about 92 x 106 daltons)
Peter Sitte, Heinz Falk, Bodo Liedvogel
openaire +3 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Cytoplasmic DNA in the unfertilized sea urchin egg: Physical properties of circular mitochondrial DNA and the occurrence of catenated forms [PDF]
, 1968 The mitochondrial DNA in the unfertilized egg of the sea urchin Lytechinus pictus is present in an amount approximately seven times that of the haploid nuclear DNA.(1) The mitochondrial DNA has a higher buoyant density than the nuclear DNA and consists ...
Blair, Donald G. +3 more
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