Results 91 to 100 of about 174,880 (353)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

More about Q-ball with elliptical orbit

open access: yesPhysics Letters B, 2019
Q-balls formed from the Affleck-Dine field have rich cosmological implications and have been extensively studied from both theoretical and simulational approaches.
Fuminori Hasegawa   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Analysis of perturbation solutions of varied thrust trajectories Final report [PDF]

open access: yes
Perturbation solution analysis of vehicle transfer from one planetary circular orbit to circular orbit around another planet using low thrust ...
Auelmann, R. R., Lane, P. T.
core   +1 more source

Next-to-leading tail-induced spin-orbit effects in the gravitational radiation flux of compact binaries

open access: yes, 2013
The imprint of non-linearities in the propagation of gravitational waves --- the tail effect --- is responsible for new spin contributions to the energy flux and orbital phasing of spinning black hole binaries.
Blanchet, Luc   +3 more
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Type I Outbursts in Low-eccentricity Be/X-Ray Binaries

open access: yes, 2019
Type I outbursts in Be/X-ray binaries are usually associated with the eccentricity of the binary orbit. The neutron star accretes gas from the outer parts of the decretion disk around the Be star at each periastron passage. However, this mechanism cannot
Franchini, Alessia, Martin, Rebecca G.
core   +2 more sources

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