Results 231 to 240 of about 2,234,197 (338)

Circular RNA therapeutics: a new class of long-acting RNA medicines for oncology, immunology, and rare diseases. [PDF]

Front Immunol
Ugwu OP, Okon MB, Ogenyi FC, Ugwu JN, Ugwu CN.   +4 more
europepmc   +1 more source

Thermally Modulated Metasurface Sensor for Dynamic and Time‐Resolved Isolation of Extracellular Vesicles

Advanced Materials, EarlyView.
A thermally adaptive plasmonic metasurface, functionalized with poly(N‐isopropylacrylamide) (PNIPAM) and anti‐CD63 antibodies, enables precise, on‐demand capture and release of extracellular vesicles (EVs). Delivering high recovery, improved purity, and intact vesicle structure, the platform offers a versatile, label‐free solution for real‐time EV ...
Beyza Nur Kucuk, Eylul Gulsen Yilmaz, Yusuf Aslan, Emre Ece, Özgecan Erdem, Murat Alp Gungen, Bengi Özgün Öztürk, Fatih Inci   +7 more
wiley   +1 more source

Circular RNA hsa_circ_0006168: A potential biomarker for the diagnosis and prognosis of prostate cancer. [PDF]

Oncol Lett
Ding Y, Liu MT, Yu N, Gao L, Chen LP.
europepmc   +1 more source

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source

EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1. [PDF]

J Cachexia Sarcopenia Muscle
Li J, Jin B, Yan Y, Chen Y, Yin X, Ren X, Li Q, Chen J, Wang S, Yang T, Zhang Y, Nie Q, Lu D, Wu M, Yu Y, Chen L, Keswani T, Li G, Cretoiu D, Bowen TS, Xiao J, Zheng Y.   +21 more
europepmc   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis. [PDF]

Int J Biol Sci
Zhou H, Ji Z, Sun H, Zhang W, Huang Y, Jin G, Cai H, Huang X, Dai J, Zhao J, Chen H, Fan S, Wu Y, Shen J.   +13 more
europepmc   +1 more source

High‐Throughput 3D Matrigel‐based Droplet Microfluidics for Single‐Cell Function‐to‐Omics Analysis of Cytotoxic Immune Cells in Solid Tumor Interactions

Advanced Materials Technologies, EarlyView.
A 3D Matrigel‐based droplet microfluidics platform that allows physiologically relevant analysis of single immune‐tumor interactions in solid tumors. By integrating real‐time functional imaging with fluorescence‐activated droplet sorting and RNA sequencing, the system links immune cytotoxic behavior to transcriptomic profiles, providing a scalable ...
Christina Sharkey, Harry Akligoh, Michael Finocchiaro, Abhishek Srihari Rampelli, Zongwei Wang, Aria F. Olumi, Tania Konry   +6 more
wiley   +1 more source

CircRM: profiling circular RNA modifications from nanopore direct RNA sequencing. [PDF]

Brief Bioinform
Li J, Chen S, Wu Z, Wang H, Xia R, Meng J, Zhang Y.   +6 more
europepmc   +1 more source