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Nuclear export of circular RNA
NatureCircular RNAs (circRNAs), which are increasingly being implicated in a variety of functions in normal and cancerous cells1-5, are formed by back-splicing of precursor mRNAs in the nucleus6-10. circRNAs are predominantly localized in the cytoplasm, indicating that they must be exported from the nucleus.
L. Ngô +15 more
semanticscholar +4 more sources
2018
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger +4 more
openaire +2 more sources
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules derived from exons by alternative mRNA splicing. Circularization of single-stranded RNA molecules was already described in 1976 for viroids in plants. Since then several additional types of circular RNAs in many species have been described such as the circular single-stranded ...
Nicole, Eger +4 more
openaire +2 more sources
Clinical Delivery of Circular RNA: Lessons Learned from RNA Drug Development.
Advanced Drug Delivery Reviews, 2023Circular RNAs (circRNA) represent a distinct class of covalently closed-loop RNA molecules, which play diverse roles in regulating biological processes and disease states. The enhanced stability of synthetic circRNAs compared to their linear counterparts
Tiana Loan Young +3 more
semanticscholar +1 more source
Circular RNAs and tuberculosis infection
International Journal of Biological Macromolecules, 2023Tuberculosis (TB) is a deadly infectious disease caused by Mycobacterium tuberculosis (Mtb) that affects the immune system chronically. Therefore, effective control and treatment of tuberculosis requires rapid and accurate diagnostic strategies. Tuberculosis has always been a global burden on health, social and economic systems due to the lack of ...
Hemati, Z. +8 more
openaire +2 more sources
Cancer Letters, 2017
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5'-terminal cap and 3'-terminal poly A tail. A large number of circRNAs have been identified through biological experiments, computational methods and high-throughput sequencing. CircRNA sequence composition determines if a given circRNA is exonic, intronic or retained-intronic.
Jun He +4 more
openaire +2 more sources
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5'-terminal cap and 3'-terminal poly A tail. A large number of circRNAs have been identified through biological experiments, computational methods and high-throughput sequencing. CircRNA sequence composition determines if a given circRNA is exonic, intronic or retained-intronic.
Jun He +4 more
openaire +2 more sources
Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.
Journal of Hepatology, 2018BACKGROUND & AIMS In recent years, circular RNAs (circRNAs) have been shown to have critical regulatory roles in cancer biology. However, the contributions of circRNAs to hepatocellular carcinoma (HCC) remain largely unknown.
Jian Yu +8 more
semanticscholar +1 more source
2018
Circular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called "back-splicing". These molecules show multiple functions, by acting as modulators of gene and miRNA expression, and may have a role in several biological processes, such
Daniele Fanale +3 more
openaire +3 more sources
Circular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called "back-splicing". These molecules show multiple functions, by acting as modulators of gene and miRNA expression, and may have a role in several biological processes, such
Daniele Fanale +3 more
openaire +3 more sources
Advances in Materials
The advancement of message RNA (mRNA) ‐based immunotherapies for cancer is highly dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid nanoparticles (LNPs).
Shufen Xu +10 more
semanticscholar +1 more source
The advancement of message RNA (mRNA) ‐based immunotherapies for cancer is highly dependent on the effective delivery of RNA (Ribonucleic) payloads using ionizable lipid nanoparticles (LNPs).
Shufen Xu +10 more
semanticscholar +1 more source
Circular RNA and its mechanisms in disease: From the bench to the clinic.
Pharmacology and Therapeutics, 2018The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise to a new perspective regarding our understanding of cellular physiology and disease pathogenesis.
B. Han, J. Chao, Honghong Yao
semanticscholar +1 more source
2018
Circular RNAs (circRNAs) constitute a class of RNAs that only recently have come into the focus of the scientific cancer community after it was revealed that they are very abundant, highly conserved across species and show tissue- and developmental stage-specific expression. This tightly regulated, dynamic circRNA expression, in line with expression of
Susanne, Lux, Lars, Bullinger
openaire +2 more sources
Circular RNAs (circRNAs) constitute a class of RNAs that only recently have come into the focus of the scientific cancer community after it was revealed that they are very abundant, highly conserved across species and show tissue- and developmental stage-specific expression. This tightly regulated, dynamic circRNA expression, in line with expression of
Susanne, Lux, Lars, Bullinger
openaire +2 more sources