Results 71 to 80 of about 1,211 (263)
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Advances in Statistics, 1997 This paper studies the conjecture that the empirical spectral distribution of an \(n\times n\) matrix of i.i.d. entries \(\xi_{kj} =(1/ \sqrt n) x_{kj}\) and \(\{x_{kj},\;k,j=1,2, \dots\}\) forming an infinite double array of i.i.d. complex random variables converges to the uniform distribution over the unit disc on the complex plane, which is called ...
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CALCULO DE ESFUERZOS MAXIMOS EN EL SUELO EN EL CASO DE CIMIENTOS CIRCULARES Y CARGA EXCENTRICA
Ingeniería, 2011 Para el diseño de cimientos circulares sujetos a cargas excéntricas, se presenta un procedmiento de cálculo simple de los esgfuerzos máximos ene el suelo, mediante la utilización de un gráfico en términos de los parámetros geométricos involucrados.
Marija Romanjek Blimel
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Um modelo discreto de partículas 2D para simulação da fratura em rocha: formulação e calibração
Geotecnia, 2013 Modelos detalhados de partículas têm sido adotados na modelação da fratura em materiais quase frágeis. Neste artigo é adotado um modelo de partículas 2D que tem sido desenvolvido tendo em vista o estudo da fratura em rocha. Os sistemas de partículas são
Nuno Azevedo, Fátima Gouveia
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Revista Árvore, 2010 Este trabalho teve o propósito de avaliar uma metodologia de amostragem que propõe o uso de parcelas circulares superpostas em inventários florestais, comparada à amostragem simples ao acaso convencional.
Thomaz Corrêa de Castro da Costa +1 more
doaj +1 more source
Recycled PLA for 3D Printing: A Comparison of Recycled PLA Filaments from Waste of Different Origins after Repeated Cycles of Extrusion. [PDF]
Polymers (Basel), 2023 Hidalgo-Carvajal D +4 more
europepmc +1 more source