Results 51 to 60 of about 22,403 (300)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Formación de redes dirigidas circulares con costos de enlace compartidos
Estudios Económicos, 2003 Formación de redes dirigidas circulares con costos de enlace ...
Juan Manuel Larrosa, Fernando Tohmé
doaj +2 more sources
Cuadernos de Geografía: Revista Colombiana de Geografía, 2015 El desarrollo de la linea de costa (DL ) es una medida morfométrica que permite conocer cuantitativamente la forma de la cubeta. El objetivo de este trabajo es comparar el DL de un grupo de lagunas que, aunque se encuentran en una misma región, son ...
Félix Ignacio Contreras +1 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Revista da Faculdade de Direito da Universidade Federal de Minas Gerais, 2014 Cobrança de tributos extra-orçamentários — A fôrça das circulares fazendárias — O pagamento do imposto — O fato gerador do imposto — Imposto e alíquota.
Alberto Deodato
doaj +4 more sources
Non-parametric methods for circular-circular and circular-linear [PDF]
, 2011 We present a non-parametric approach for the estimation of the bivariate distribution of two circular variables and the modelling of the joint distribution of a circular and a linear variable. We combine nonparametric estimates of the marginal densities of the circular and linear components with the use of class of nonparametric copulas, known as ...
Ausín Olivera, María Concepción +2 more
openaire +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Modelos de Negocios Circulares
, 2020 Universidad Viña del Mar Con el objetivo de entregar contenidos sobre economía sustentable para empresas y desarrollo de modelos de negocios circulares basados en los pilares económicos, sociales y medio ambientales, la Universidad Viña del Mar (UVM ...
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