Results 31 to 40 of about 1,211 (263)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo   +5 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Las normas administrativas y el sistema de fuentes Administrative Norms and the Sources of Law System

open access: yesRevista de Derecho (Coquimbo), 2010
En esta investigación se analiza, desde una perspectiva general, la naturaleza, fundamentos y efectos de las diversas normas que emanan de los órganos de la Administración del Estado, con el objeto de establecer un marco general para comprender la forma ...
Eduardo Cordero Quinzacara
doaj  

Laminas cilíndricas circulares. Una solución aproximada

open access: yesInformes de la Construccion, 1984
Se presenta en este trabajo una simplificación del análisis de las láminas cilíndricas de directriz circular proponiendo una solución aproximada obtenida por la descomposición del trabajo total en dos más sencillos: el longitudinal y el transversal ...
Juan Cerdó Pons
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Los diagramas circulares del Códice Pérez.

open access: yesAnales del Instituto de Investigaciones Estéticas, 2019
Este artículo estudia los diagramas circulares en el Códice Pérez, un documento compilado por Juan Pío Pérez en la primera mitad del siglo XIX y que reúne textos de diferentes manuscritos de los conocidos como libros de Chilam Balam. Estas imágenes, que
Florencia Scandar
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Tarjetas de Estrategias Circulares como herramienta de ideación en el diseño circular

open access: yesLa Tadeo DeArte
Este artículo presenta las Tarjetas de Estrategias Circulares como una de las herramientas principales de pensamiento visual desarrollada en el marco del proyecto de investigación “Creación de un modelo metodológico de diseño circular basado en la ...
Aida Manrique Lopez   +1 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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