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Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome
Clinical Diagnostic Laboratory Immunology, 1996The systemic inflammatory response of the body to invading microorganisms, termed sepsis, leads to profound activation of the complement system. Pathophysiological concepts suggest that complement activation occurs very early in this syndrome. Thus, we discuss whether the determination of concentrations of the complement components C3a, C5a, and C3 in ...
S, Stöve +6 more
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The American Journal of Cardiology, 2021
Fontan palliation has improved survival for single ventricle patients, but long-term complications persist including cardiovascular dysfunction, neurohormonal abnormalities, and protein-losing enteropathy (PLE). Although chronic inflammation contributes to morbidity, an association between inflammation and vascular dysfunction has not been studied.
Lauren N. Manning +6 more
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Fontan palliation has improved survival for single ventricle patients, but long-term complications persist including cardiovascular dysfunction, neurohormonal abnormalities, and protein-losing enteropathy (PLE). Although chronic inflammation contributes to morbidity, an association between inflammation and vascular dysfunction has not been studied.
Lauren N. Manning +6 more
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Circulating soluble vascular adhesion protein 1 in patients with inflammatory bowel disease
European Journal of Gastroenterology & Hepatology, 2002A dysregulated local immune defence with a constant influx of leucocytes provides a basis for continuous intestinal inflammation in ulcerative colitis and Crohn's disease. Since vascular adhesion protein 1 (VAP-1) is one of the adhesion molecules that mediates lymphocyte binding to endothelium, we investigated the levels of soluble VAP-1 (sVAP-1) in ...
Ioannis E, Koutroubakis +6 more
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Journal of Crohn’s and Colitis
Abstract Background Biological mechanisms driving disease progression in patients with inflammatory bowel disease (IBD) are incompletely understood. While proteomic studies in IBD have largely focused on disease determinants and changes at pre- and post-diagnostic stages, identification of ...
F Veenstra +10 more
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Abstract Background Biological mechanisms driving disease progression in patients with inflammatory bowel disease (IBD) are incompletely understood. While proteomic studies in IBD have largely focused on disease determinants and changes at pre- and post-diagnostic stages, identification of ...
F Veenstra +10 more
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Neurological Sciences
Myasthenia gravis (MG) is a neurological immune-mediated disorder affecting approximately three million people worldwide. While specific circulating inflammatory proteins (CIPs), including cytokines and chemokines, have been strongly implicated in the pathogenesis of MG, their causal roles remain poorly understood.A cis-Mendelian randomization (MR ...
Kangzhi Chen +6 more
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Myasthenia gravis (MG) is a neurological immune-mediated disorder affecting approximately three million people worldwide. While specific circulating inflammatory proteins (CIPs), including cytokines and chemokines, have been strongly implicated in the pathogenesis of MG, their causal roles remain poorly understood.A cis-Mendelian randomization (MR ...
Kangzhi Chen +6 more
openaire +2 more sources
Applied Biochemistry and Biotechnology, 2009
Proposed methods for detecting circulatory system disease include targeting ultrasound contrast agents to inflammatory markers on vascular endothelial cells. For antibody-based therapies, soluble forms of the targeted adhesion proteins of the immunoglobulin superfamily (IgSF) reduce adhesion yet were left unaccounted in prior reports.
Matthew B, Kerby +3 more
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Proposed methods for detecting circulatory system disease include targeting ultrasound contrast agents to inflammatory markers on vascular endothelial cells. For antibody-based therapies, soluble forms of the targeted adhesion proteins of the immunoglobulin superfamily (IgSF) reduce adhesion yet were left unaccounted in prior reports.
Matthew B, Kerby +3 more
openaire +2 more sources
International Archives of Allergy and Immunology
Introduction: Allergic rhinitis (AR) is a common chronic allergic inflammatory disease, and circulating inflammatory markers have been found to play an important role in the pathogenesis of AR. The aim of this study was to elucidate the causal relationship between 91 circulating inflammatory markers and AR using Mendelian randomization (MR) analysis ...
Hui, Zhang +4 more
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Introduction: Allergic rhinitis (AR) is a common chronic allergic inflammatory disease, and circulating inflammatory markers have been found to play an important role in the pathogenesis of AR. The aim of this study was to elucidate the causal relationship between 91 circulating inflammatory markers and AR using Mendelian randomization (MR) analysis ...
Hui, Zhang +4 more
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Seminars in Thrombosis and Hemostasis
AbstractPortal vein thrombosis (PVT) is commonly encountered in patients with cirrhosis, challenging our understanding of its development, particularly the ambiguous contribution of inflammation. This study utilized Mendelian randomization (MR) to explore the causal impact of circulating inflammatory markers on PVT.Employing a two-sample MR framework ...
Bihui, Zhang +7 more
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AbstractPortal vein thrombosis (PVT) is commonly encountered in patients with cirrhosis, challenging our understanding of its development, particularly the ambiguous contribution of inflammation. This study utilized Mendelian randomization (MR) to explore the causal impact of circulating inflammatory markers on PVT.Employing a two-sample MR framework ...
Bihui, Zhang +7 more
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Cardiovascular Toxicology
Calcific aortic valve stenosis (CAVS) is characterized by increasing inflammation and progressive calcification in the aortic valve leaflets and is a major cause of death in the aging population. This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets.
Rui, Lin +5 more
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Calcific aortic valve stenosis (CAVS) is characterized by increasing inflammation and progressive calcification in the aortic valve leaflets and is a major cause of death in the aging population. This study aimed to identify the inflammatory proteins involved in CAVS and provide potential therapeutic targets.
Rui, Lin +5 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Heather A Parsons +2 more
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