Results 91 to 100 of about 503,944 (360)

Understanding Arctic Ocean Circulation: A Review of Ocean Dynamics in a Changing Climate

open access: yes, 2020
12 The Arctic Ocean is a focal point of climate change, with ocean warming, freshening, 13 sea-ice decline and circulation that link to the changing atmospheric and terrestrial en14 vironment. Major features of the Arctic and the interconnected nature of
M. Timmermans, J. Marshall
semanticscholar   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Computational fluid dynamics study of yield power law drilling fluid flow through smooth-walled fractures

open access: yesJournal of Petroleum Exploration and Production Technology, 2019
Presence of natural fractures in sub-surface makes an oil well drilling operation very challenging. As one of the major functions of drilling mud is to maintain bottomhole pressure inside a wellbore to avoid any invasion of unwanted high-pressure influx (
Faysal Ahammad   +2 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Optimization of Meridional Flow Channel Design of Pump Impeller

open access: yesInternational Journal of Rotating Machinery, 2004
The meridional flow channel design of a pump impeller affects its performance. However, since so many design parameters exist, a new design method is proposed in which a meridional and blade-to-blade flow channel is designed by the parallel use of the ...
Sunao Miyauchi   +3 more
doaj   +1 more source

Changing the Currently Held Concept of Cerebrospinal Fluid Dynamics Based on Shared Findings of Cerebrospinal Fluid Motion in the Cranial Cavity Using Various Types of Magnetic Resonance Imaging Techniques

open access: yesNeurologia medico-chirurgica, 2019
The “cerebrospinal fluid (CSF) circulation theory” of CSF flowing unidirectionally and circulating through the ventricles and subarachnoid space in a downward or upward fashion has been widely recognized.
M. Matsumae   +7 more
semanticscholar   +1 more source

Cauchy's almost forgotten Lagrangian formulation of the Euler equation for 3D incompressible flow

open access: yes, 2014
Two prized papers, one by Augustin Cauchy in 1815, presented to the French Academy and the other by Hermann Hankel in 1861, presented to G\"ottingen University, contain major discoveries on vorticity dynamics whose impact is now quickly increasing ...
Frisch, Uriel, Villone, Barbara
core   +1 more source

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

Validation of actuator disc circulation distribution for unsteady virtual blades model

open access: yesTheoretical and Applied Mechanics Letters, 2021
The actuator disc method is an engineering approach to reduce computer resources in computational fluid dynamics (CFD) simulations of helicopter rotors or aeroplane propellers.
A. N. Kusyumov   +3 more
doaj  

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