Results 161 to 170 of about 45,939 (308)

Modeling of integrated fluid dynamics of cerebral circulation and cerebrospinal fluid flow

Modeling of integrated fluid dynamics of cerebral circulation and cerebrospinal fluid flow
Objectives:In the fluid dynamics of cerebral circulation and cerebrospinal fluid (CSF) motion, the computational simulation model has not been established. We conducted the multi-scale simulation in the cerebral circulation model. Therefore, we would like to integrate these two different fluid dynamics models.
openaire  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Cerebrospinal fluid dynamics and brain function regulation: from homeostasis to neurological disorders. [PDF]

Front Neurosci
Yang Y, Jia H, Liu H.
europepmc   +1 more source

Modelling vortex-vortex and vortex-boundary interaction

, 2010
The motion of two-dimensional inviscid, incompressible fluid with regions of constant vorticity is studied for three classes of geophysically motivated problem. First, equilibria consisting of point vortices located near a vorticity interface generated
Nelson, R.B.
core  

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Selection of revision technique for suboptimal total cavopulmonary connection based on computational fluid dynamics: a case report. [PDF]

J Cardiothorac Surg
Matsuo S, Ota C, Ota H, Saiki Y.
europepmc   +1 more source

Turbulent natural convection in an air-water system with evaporation across the free surface

In this talk, we present results from direct numerical simulations of turbulent convection in a pool that contains liquid water in the lower part and air in the upper one.
Carlier, Julien, Papalexandris, Miltiadis, 1st European Fluid Dynamics Conference   +2 more
core  

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Comprehensive Review on the Droplet Dynamics of an Acoustically Levitated Colloidal Droplet. [PDF]

Langmuir
Selvaraju R, Kureshee A, Kannaiyan K.
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source