Results 181 to 190 of about 45,939 (308)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

A Multidisciplinary Approach to Patient-Specific Surgical Planning in Congenital Heart Disease∗

JACC: Advances
Rachel D. Vanderlaan, MD, PhD, Alessia Di Nardo, BEng, Cristina H. Amon, ScD   +2 more
doaj   +1 more source

A monolithic patient-specific 3D-0D model for In silico investigation of hemodynamics in patients with left ventricular assist devices. [PDF]

Biomech Model Mechanobiol
Bonini M, Hirschvogel M, Ferguson M, Pagani F, Tang PC, Nordsletten D.   +5 more
europepmc   +1 more source

LES Exploration of the Near and Far Wake of Wings using a Novel Lifting and Dragging Line Model

, 2019
Several wing wakes are investigated by means of a hybrid Vortex Particle-Mesh-based LES flow solver, elected for its ability to capture wake dynamics with minimal spurious dispersion and diffusion.
Winckelmans, Grégoire, Caprace, Denis-Gabriel, 72nd Annual Meeting of the APS Division of Fluid Dynamics, Chatelain, Philippe   +3 more
core  

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

One-dimensional computational circulatory models: a scoping review. [PDF]

Einstein (Sao Paulo)
Nóbrega GACL, Garzon S, Blanco PJ, Lemos Neto PA.   +3 more
europepmc   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

Hydrothermal system dynamics at Pisciarelli fumarole field (Campi Flegrei): insights from geophysical and numerical modelling. [PDF]

Sci Rep
Salone R, Troiano A, Di Giuseppe MG, Isaia R, Di Maio R.   +4 more
europepmc   +1 more source

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Dynamic confinement controls the porous-to-free convection transition. [PDF]

Proc Natl Acad Sci U S A
Schwendener DM, Noir J, Latt J, Coreixas C, Kong XZ.   +4 more
europepmc   +1 more source