Results 31 to 40 of about 641,936 (267)
A comparison of the atmospheric response to the Weddell Sea Polynya in atmospheric general circulation models (AGCMs) of varying resolutions [PDF]
Weather and Climate DynamicsThe Weddell Sea Polynya (WSP) is a large opening within the sea ice cover of the Weddell Sea sector. It has been a rare event in the satellite period, appearing between 1973 and 1976 and again in 2016/2017.
H. C. Ayres +8 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
DEFINITIONS OF THE REAL ESTATE TURNOVER SYSTEM
Russian Journal of Economics and Law, 2014 Objective: to study the principles and the role of legislative definitions within the various research methods for modeling functions of legal models of the civil rights objects. Methods: method of comparative analysis and abstract method. Results: the
V. A. Petrushkin
doaj
Atmosphere, 2017 The observed convective adjustment time (CAT) associated with Madden–Julian Oscillation (MJO) precipitation is found to vary significantly in space. Here, we investigate the effect of different spatial distributions of CAT on MJO precipitation based on ...
Hui Wang, Yuntao Wei, Fei Liu
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Frontiers in Marine ScienceIntroductionUnderstanding the underlying dynamics of regional sea-level rise (SLR), which often deviates from global trends, is crucial for mitigating and adapting to the impacts of severe climate change.
KyungJae Lee +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source