Results 121 to 130 of about 680,529 (391)

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Predictive model of in-hospital mortality in liver cirrhosis patients with hyponatremia: an artificial neural network approach

Scientific Reports
Hyponatremia can worsen the outcomes of patients with liver cirrhosis. However, it remains unclear about how to predict the risk of death in cirrhotic patients with hyponatremia. Patients with liver cirrhosis and hyponatremia were screened.
Zhaohui Bai, Yuhang Yin, Wentao Xu, Gang Cheng, Xingshun Qi   +4 more
doaj   +1 more source

Characteristics of bacterial infections and prevalence of multidrug-resistant bacteria in hospitalized patients with liver cirrhosis in Germany

Annals of Hepatology, 2022
Introduction and Objectives: Bacterial infections are associated with a dismal prognosis in patients with liver cirrhosis. Data on their prevalence and the associated pathogen spectra in Germany are scarce.
Wolfgang Maximilian Kremer, Simon Johannes Gairing, Leonard Kaps, Esmeralda Ismail, Vasiliki Kalampoka, Max Hilscher, Maurice Michel, Ekkehard Siegel, Jörn M. Schattenberg, Peter R. Galle, Martin F. Sprinzl, Marcus-Alexander Wörns, Michael Nagel, Christian Labenz   +13 more
doaj  

Symptom Domain Groups of the Patient-Reported Outcomes Measurement Information System Tools Independently Predict Hospitalizations and Re-hospitalizations in Cirrhosis [PDF]

, 2017
Background Patient-Reported Outcomes Measurement Information System (PROMIS) tools can identify health-related quality of life (HRQOL) domains that could differentially affect disease progression.
Bajaj, Jasmohan S., Fagan, Andrew, Fuchs, Michael, Gavis, Edith A., Luketic, Velimir A., Matherly, Scott, Patidar, Kavish R., Puri, Puneet, Sanyal, Arun J., Siddiqui, Mohammad S., Sterling, Richard K., Stravitz, Richard T., Thacker, Leroy R., Wade, James B., White, Melanie B.   +14 more
core   +2 more sources

Sarcopenia in cirrhosis: from pathogenesis to interventions

Journal of gastroenterology, 2019
Sarcopenia (severe muscle depletion) is a prevalent muscle abnormality in patients with cirrhosis that confers poor prognosis both pre- and post-liver transplantation. The pathogenesis of sarcopenia is multifactorial and results from an imbalance between
M. Ebadi, R. Bhanji, V. Mazurak, A. Montaño-Loza   +3 more
semanticscholar   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

Improved quality of life in patients with refractory or recidivant ascites after insertion of transjugular intrahepatic portosystemic shunts [PDF]

, 2002
Background. We have recently shown that the transjugular intrahepatic portosystemic shunt (TIPS) is more effective than paracentesis in the treatment of cirrhotic patients with severe ascites and can prolong survival in selected patients.
Bilzer, M., Gerbes, Alexander L., Gülberg, Veit, Liss, I., Reiser, Maximilian F., Waggershauser, T.   +5 more
core   +1 more source

Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis.

New England Journal of Medicine, 2014
BACKGROUND High rates of sustained virologic response were observed among patients with hepatitis C virus (HCV) infection who received 12 weeks of treatment with the nucleotide polymerase inhibitor sofosbuvir combined with the NS5A inhibitor ledipasvir ...
K. Kowdley, S. Gordon, K. Reddy, L. Rossaro, D. Bernstein, E. Lawitz, M. Shiffman, E. Schiff, R. Ghalib, M. Ryan, V. Rustgi, M. Chojkier, R. Herring, A. D. Di Bisceglie, P. Pockros, G. Subramanian, D. An, E. Svarovskaia, R. Hyland, P. Pang, W. Symonds, J. Mchutchison, A. Muir, D. Pound, M. Fried   +24 more
semanticscholar   +1 more source

Hyponatremia in cirrhosis [PDF]

Journal of Hospital Medicine, 2012
AbstractHyponatremia is common in patients with cirrhosis. Portal hypertension, diuretics, large volume paracentesis without albumin, infection, and multiple medications are connected with the development or worsening of hyponatremia. Hyponatremia in cirrhosis, particularly advanced cirrhosis, is a common development.1 In a population survey of 997 ...
openaire   +3 more sources

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science, EarlyView.
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
wiley   +1 more source