Results 251 to 260 of about 419,003 (365)

Confirmatory Biomarker Identification via Derandomized Knockoffs for Cox Regression with k-FWER Control [PDF]

open access: yesarXiv
Selecting important features in high-dimensional survival analysis is critical for identifying confirmatory biomarkers while maintaining rigorous error control. In this paper, we propose a derandomized knockoffs procedure for Cox regression that enhances stability in feature selection while maintaining rigorous control over the k-familywise error rate (
arxiv  

Plasma metabolomics identifies signatures that distinguish heart failure with reduced and preserved ejection fraction

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Two general phenotypes of heart failure (HF) are recognized: HF with reduced ejection fraction (HFrEF) and with preserved EF (HFpEF). To develop phenotype‐specific approaches to treatment, distinguishing biomarkers are needed. The goal of this study was to utilize quantitative metabolomics on a large, diverse population to replicate and ...
Fawaz Naeem   +13 more
wiley   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

open access: yesHepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang   +18 more
wiley   +1 more source

Myelopathy in cirrhosis [PDF]

open access: yesSpinal Cord, 1978
Andre Anzarut, C E Robinson
openaire   +2 more sources

BUN‐to‐ALB ratio as an effective predictor of 30 day mortality in ADHF patients in eastern China

open access: yesESC Heart Failure, EarlyView.
Abstract Aims The blood urea nitrogen‐to‐albumin ratio (BAR) is considered a potential indicator for assessing the poor prognosis of heart failure (HF). However, its prognostic value for Chinese patients with acute decompensated HF (ADHF) remains unclear.
Xin Huang   +8 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

open access: yesHepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog   +12 more
wiley   +1 more source

Plasma volume status predicting clinical outcomes in patients undergoing transcatheter edge‐to‐edge mitral valve repair

open access: yesESC Heart Failure, EarlyView.
Abstract Aims Plasma volume status (PVS) is recognized as a marker of systemic congestion, but its clinical utility in patients with mitral regurgitation (MR) undergoing transcatheter edge‐to‐edge mitral valve repair (M‐TEER) has not been well established. This study aimed to evaluate the prognostic significance of PVS in these patients.
Ai Kagase   +30 more
wiley   +1 more source

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