Results 81 to 90 of about 691,603 (403)

The Royal Free Hospital score: a calibrated prognostic model for patients with cirrhosis admitted to intensive care unit. Comparison with current models and CLIF-SOFA score [PDF]

, 2014
Prognosis for patients with cirrhosis admitted to intensive care unit (ICU) is poor. ICU prognostic models are more accurate than liver-specific models.
Agarwal, B, Burroughs, AK, Cheung, M, Cholongitas, E, Mohammad, AO, Pieri, G, Theocharidou, E   +6 more
core   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion

Stem Cells International, 2016
Profibrogenesis cytokine, transforming growth factor- (TGF-) β1, induces hepatic progenitors experiencing epithelial to mesenchymal transition (EMT) to matrix synthesis cells, even tumor initiating cells.
Ping Wang, Min Cong, Tianhui Liu, Aiting Yang, Guangyong Sun, Dong Zhang, Jian Huang, Shujie Sun, Jia Mao, Hong Ma, Jidong Jia, Hong You   +11 more
doaj   +1 more source

An Analysis of Immunoreactive Signatures in Early Stage Hepatocellular Carcinoma

EBioMedicine, 2015
Background: Hepatocellular carcinoma (HCC) is prevalent worldwide and early diagnosis of HCC is critical for effective treatment and optimal prognosis.
Yu Hong, Jiang Long, Hai Li, Shuhong Chen, Qiqi Liu, Bei Zhang, Xiaomin He, Yan Wang, Hongyi Li, Yimei Li, Tao Zhang, Chenzhen Lu, Hao Yan, Minli Zhang, Qing Li, Bangwei Cao, Zhigang Bai, Jin Wang, Zhongtao Zhang, Shengtao Zhu, Jiasheng Zheng, Xiaojuan Ou, Hong Ma, Jidong Jia, Hong You, Shengqi Wang, Jian Huang   +26 more
doaj   +1 more source

Hyponatremia in cirrhosis [PDF]

Journal of Hospital Medicine, 2012
AbstractHyponatremia is common in patients with cirrhosis. Portal hypertension, diuretics, large volume paracentesis without albumin, infection, and multiple medications are connected with the development or worsening of hyponatremia. Hyponatremia in cirrhosis, particularly advanced cirrhosis, is a common development.1 In a population survey of 997 ...
openaire   +3 more sources

Orthotopic liver transplantation for alcoholic cirrhosis. [PDF]

, 1988
Fifteen patients with Laennec's cirrhosis underwent orthotopic liver transplantation between 1963 and the end of 1979. The first eight patients died perioperatively or within two months, but four of the next seven patients had long survival; three are ...
Gordon, RD, Iwatsuki, S, Koneru, B, Marsh, JW, Starzl, TE, Staschak, S, Stieber, A, Todo, S, Tzakis, AG, Van Thiel, D   +9 more
core   +1 more source

Diagnosis and management of acute kidney injury in patients with cirrhosis: revised consensus recommendations of the International Club of Ascites

Gut, 2015
Acute renal failure (ARF) is a common complication in patients with decompensated cirrhosis. The traditional diagnostic criteria of renal failure in these patients were proposed in 19961 and have been refined in subsequent years.2 According to these ...
P. Angeli, P. Ginés, F. Wong, M. Bernardi, T. Boyer, A. Gerbes, Richard Moreau, Richard Moreau, R. Jalan, S. Sarin, S. Piano, K. Moore, Samuel S. Lee, F. Durand, F. Salerno, P. Caraceni, W. Kim, V. Arroyo, G. Garcia‐Tsao   +18 more
semanticscholar   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Association of blood cadmium levels with all-cause and cause-specific mortality among adults with non-alcoholic fatty liver disease: a prospective cohort study

Frontiers in Public Health
BackgroundCadmium (Cd) accumulates in the body over time, damaging organs such as the liver, kidneys, and brain. Some researchers have suggested that elevated blood Cd levels may contribute to the onset and progression of nonalcoholic fatty liver disease
Congxi Xu, Congxi Xu, Zhi Li, Shirui Hao, Jian Zhang, Jinlong Li, Kuopeng Liang, Xiaojuan Wang, Yi Zhang, Yi Zhang, Guangyuan Zhao, Mengyun Bai, Dengxiang Liu, Jitao Wang   +13 more
doaj   +1 more source

Presence of multiple bacterial markers in clinical samples might be useful for presumptive diagnosis of infection in cirrhotic patients with culture-negative reports [PDF]

, 2016
Bacterial infections in cirrhotic patients with ascites are associated with a severe prognosis and an increased risk of death. The microbiological standard tests for the diagnosis of suspected infection, based on culture test of blood and ascitic fluid ...
Boaretti, M, Castellani, F, Lleo, M. M., Lucidi, Cristina, Merli, Manuela   +4 more
core   +1 more source