Results 81 to 90 of about 448,681 (368)

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source

HFE-Related Hemochromatosis in a Chinese Patient: The First Reported Case

Frontiers in Genetics, 2020
HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry.
Wei Zhang, Wei Zhang, Wei Zhang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Weijia Duan, Weijia Duan, Weijia Duan, Anjian Xu, Anjian Xu, Anjian Xu, Xinyan Zhao, Xinyan Zhao, Xinyan Zhao, Jian Huang, Jian Huang, Jian Huang, Jian Huang, Hong You, Hong You, Hong You, Pierre Brissot, Xiaojuan Ou, Xiaojuan Ou, Xiaojuan Ou, Jidong Jia, Jidong Jia, Jidong Jia   +28 more
doaj   +1 more source

Maximum likelihood and pseudo score approaches for parametric time-to-event analysis with informative entry times [PDF]

Annals of Applied Statistics 2014, Vol. 8, No. 2, 726-746, 2014
We develop a maximum likelihood estimating approach for time-to-event Weibull regression models with outcome-dependent sampling, where sampling of subjects is dependent on the residual fraction of the time left to developing the event of interest. Additionally, we propose a two-stage approach which proceeds by iteratively estimating, through a pseudo ...
arxiv   +1 more source

Amiloride reduces portal hypertension in rat liver cirrhosis [PDF]

, 2010
Objective This study aimed to investigate the effect of amiloride on portal hypertension. Amiloride is known to inhibit Na(+)/H(+) exchangers on activated hepatic stellate cells.
Beitinger, Frigga, Bystron, Markus, De Toni, Enrico N., Gerbes, Alexander L., Hartmann, Anna C., Hennenberg, Martin, Steib, Christian J.   +6 more
core   +1 more source

The Antiviral Efficacy and Safety of Azvudine in Hospitalized SARS‐CoV‐2 Infected Patients with Liver Diseases Based on a Multicenter, Retrospective Cohort Study

Advanced Science, EarlyView.
Azvudine shows benefits in reducing all‐cause mortality in hospitalized SARS‐CoV‐2 infected patients and liver diseases. COVID‐19 patients with kidney disease and without autoimmune diseases show a preference for azvudine. Azvudine may be a promising antiviral agent for treating COVID‐19 concomitant with liver diseases.
Junyi Sun, Mengzhao Yang, Guanyue Su, Ling Wang, Xiaobo Hu, Yongjian Zhou, Guangying Cui, Guowu Qian, Yiqiang Yuan, Xinjun Hu, Silin Li, Hong Luo, Shixi Zhang, Guangming Li, Donghua Zhang, Guotao Li, Ming Cheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Simultaneous splenectomy improving the outcomes of patients with hepatocellular carcinoma, cirrhosis and portal hypertension treated with hepatectomy

Portal Hypertension & Cirrhosis, 2022
Aims Patients with cirrhosis and clinically significant portal hypertension (CSPH) usually have concomitant secondary hypersplenism, and splenectomy (Spx) is an option for treating these patients in the Asia‐Pacific region.
Fuchen Liu, Xinggang Guo, Wenli Zhang, Minghao Zou, Jian Huang, Wei Dong, Jinmin Zhang, Xiuli Zhu, Zeya Pan, Wan Yee Lau, Weiping Zhou, Hui Liu   +11 more
doaj   +1 more source

Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis [PDF]

, 1991
In 11 patients with decompensated cirrhosis and deteriorating renal function, the effect of the vasoconstrictor substance 8-ornithin vasopressin (ornipressin; POR 8; Sandoz, Basel, Switzerland) on renal function, hemodynamic parameters, and humoral ...
Alexander L. Gerbes, Anton Laggner, Arendt, Barratt-Boyes, Barry, Bauch, Brenner, Bruno Schneeweiss, Burnett, Cohn, Davies, Epstein, Epstein, Epstein, Fernandez-Seara, Fischer, Fried, Fyrquist, Ganger, Ganong, Georg Grimm, Gerbes, Gerbes, Gerbes, Gerbes, Gornel, Granger, Haber, Harald Reither, Heide Hörtnagl, Heinrich, Heyndrickx, Hintze, Holtz, Hörtnagl, Katsube, Kew, Klepetko, Koepke, Kontos, Kotelanski, Kurt Lenz, Lancestremere, Lenz, Lenz, Lenz, López, Manning, Marin-Grez, Murray, Needleman, Nicholls, Oshima, Panos, Petrillo, Rainer Schmid, Richards, Salerno, Salerno, Schenker, Schmid, Schrier, Shapiro, Siegel, Solis-Herruzo, Wernze, Wilfred Druml   +66 more
core   +1 more source

FGF2 Mediated USP42‐PPARγ Axis Activation Ameliorates Liver Oxidative Damage and Promotes Regeneration

Advanced Science, EarlyView.
USP42 is identified as a novel DUB of PPARγ in hepatocytes. USP42 mediated PPARγ deubiquitylation determines its transcriptional preference on proliferative and redox balance genes. USP42 knockdown exacerbates liver damage and delays regeneration. FGF2 is the upstream signal that initiates and activates the USP42‐PPARγ axis.
Nanfei Yang, Qiang Tian, Zhenli Lei, Shuxin Wang, Nan Cheng, Zhen Wang, Xianqin Jiang, Xuqun Zheng, Wenjing Xu, Minyan Ye, Longwei Zhao, Meiyun Wen, Jianlou Niu, Weijian Sun, Pingping Shen, Zhifeng Huang, Xiaokun Li   +16 more
wiley   +1 more source

A comprehensive review of prognostic scoring systems to predict survival after transjugular intrahepatic portosystemic shunt placement

Portal Hypertension & Cirrhosis, 2022
Patient prognosis after transjugular intrahepatic portosystemic shunt (TIPS) placement is relatively poor and highly heterogeneous; therefore, a prognostic scoring system is essential for survival prediction and risk stratification.
Chongtu Yang, Bin Xiong
doaj   +1 more source

Sex Differences in the Association Between Frailty and Sarcopenia in Patients With Cirrhosis. [PDF]

, 2019
ObjectivesFrailty is prevalent in patients with cirrhosis and is hypothesized to result in part from sarcopenia, but the precise contribution of sarcopenia to frailty in this population is poorly understood.MethodsIncluded were patients with cirrhosis ...
Bhanji, Carey, Dasarathy, DiMartini, Englesbe, Fried, Kuo, Lai, Lai, Lai, Lang, Montano-Loza, Montano-Loza, Riggio, Sinclair, Tandon, Wang, Yadav   +17 more
core   +2 more sources