Results 111 to 120 of about 1,056,457 (311)

Las deudas pendientes de Latinoamérica.

open access: yes, 2018
La décima versión de la Cátedra Alberto Hurtado de Liderazgo Social, organizada por el Centro de Reflexión y Acción Social (CREAS) de la Universidad Alberto Hurtado en conjunto con el Centro de Investigación Social (CIS) de Un Techo para Chile, se llevó ...
CIS Chile
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

cis-reQTL mapping and SLC45A2 reQTL.

open access: yes, 2016
(A) Outline of the approach for mapping cis-reQTLs (B) QQ plot of the cis-reQTL p-value for all genes tested. Red indicates the top 3 genes discussed in the text and used in subsequent analyses.
Ryosuke Kita (461005)   +1 more
core   +1 more source

Retinol dehydrogenases in retinoid metabolism : studies on a 9-cis/11-cis-retinol dehydrogenase in adult and embryonic tissues

open access: yes, 2000
Retinoids (vitamin A derivatives) are necessary for normal embryonic development and in the adult, for vision, differentiation of various epithelia, reproduction and in the immune system.
Anna Romert (19528807)
core   +1 more source

Students’ International Academic Mobility in the Context of Internationalization of Higher Education (RUDN University Case)

open access: yesVestnik RUDN. International Relations, 2019
The relevance of the research topic is due to the growing role of student mobility as a form of internationalization of higher education in Russia. In recent years higher education has become more widespread and available, influenced by the development ...
Nazym Bakytzhanovna Imankulova   +1 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Discapacidad, trabajo y bienestar

open access: yes
Este trabajo está financiado por el Centro de Investigaciones Sociológicas (CIS)versión ...
Romero Ródenas, María José   +1 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Drivers of exchange rate dynamics in selected CIS countries: Evidence from a FAVAR analysis [PDF]

open access: yes
We investigate the likely sources of exchange rate dynamics in selected CIS countries (Russia, Kazakhstan, Ukraine, Kyrgyzstan, Azerbaijan, and Moldova) over the last dec-ade (1999-2010).
Christian Dreger, Jarko Fidrmuc
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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