Results 91 to 100 of about 1,162,420 (313)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Rural Geography in Russia, Ukraine and in Belarus - a literature review

Hungarian Geographical Bulletin, 2011
The article is an overview of the literature on rural geography published in the Commonwealth of Independent States during the two decades that passed since the breakup of the Soviet Union. First, a brief review of the Soviet period is presented.
Dávid Karácsonyi
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Students’ International Academic Mobility in the Context of Internationalization of Higher Education (RUDN University Case)

Vestnik RUDN. International Relations, 2019
The relevance of the research topic is due to the growing role of student mobility as a form of internationalization of higher education in Russia. In recent years higher education has become more widespread and available, influenced by the development ...
Nazym Bakytzhanovna Imankulova, Gabriel Alekseevna Moshlyak   +1 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Enhancer divergence and cis-regulatory evolution in the human and chimp neural crest

Cell, 2015
Summary Cis-regulatory changes play a central role in morphological divergence, yet the regulatory principles underlying emergence of human traits remain poorly understood.
S. Prescott, R. Srinivasan, Maria Carolina Marchetto, I. Grishina, I. Narvaiza, L. Selleri, F. Gage, T. Swigut, J. Wysocka   +8 more
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Mapping cis- and trans-regulatory effects across multiple tissues in twins

Nature Genetics, 2012
Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals.
E. Grundberg, K. Small, Å. Hedman, Alexandra C. Nica, A. Buil, S. Keildson, J. Bell, Tsun-Po Yang, Eshwar Meduri, Amy Barrett, J. Nisbett, Magdalena Sekowska, Alicja E Wilk, So-Youn Shin, D. Glass, M. Travers, J. Min, S. Ring, Karen M. Ho, G. Thorleifsson, A. Kong, U. Thorsteindottir, C. Ainali, A. Dimas, N. Hassanali, Catherine E. Ingle, D. Knowles, Maria Krestyaninova, Christopher E. Lowe, P. Di Meglio, Stephen B. Montgomery, L. Parts, Simon C. Potter, G. Surdulescu, Loukia G Tsaprouni, S. Tsoka, V. Bataille, R. Durbin, F. Nestle, S. O’Rahilly, N. Soranzo, C. Lindgren, K. Zondervan, K. Ahmadi, E. Schadt, K. Stefánsson, G. Smith, M. McCarthy, P. Deloukas, E. Dermitzakis, T. Spector   +50 more
semanticscholar   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Optimization of a HPLC procedure for simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxoplatinum(IV) in aqueous solutions

Química Nova, 2011
A RP-HPLC procedure for the simultaneous determination of cisplatin and the complex cis,cis,trans-diamminedichlorodihydroxo-platinum(IV), was development.
Yalexmi Ramos, Carlos Hernández, Lidia Asela Fernandez, Mayra Bataller, Eliet Veliz, Renny Small   +5 more
doaj   +1 more source