Results 221 to 230 of about 1,162,420 (313)

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Isomer-Dependent Pharmacokinetic Behavior and VKOR Interactions of Second-Generation Anticoagulant Rodenticides: An Integrated In Vivo-In Vitro-In Silico Investigation. [PDF]

Int J Mol Sci
Miyamae M, Nagaoka S, Hayama T, Fukamatsu M, Kamata R, Takeda K.   +5 more
europepmc   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Recurrent Benign Contrast-Induced Sialadenitis: A Case Report. [PDF]

Cureus
Iizuka Y, Kamimura E, Kanetsuki I, Hidaka M, Morita Y, Noguchi T, Sato T.   +6 more
europepmc   +1 more source

Longitudinal Changes in Adiposity After a Youth Sport‐Related Knee Injury: Informing Posttraumatic Osteoarthritis Prevention

Arthritis Care &Research, EarlyView.
Objective Youth who experience a sport‐related knee injury have elevated odds of becoming overweight or developing obesity in 3 to 10 years, compounding their risk for posttraumatic osteoarthritis (PTOA). To inform prevention strategies, this study compared patterns of adiposity change between youth with a sport‐related knee injury and uninjured youth ...
Justin M. Losciale, Nuria E. J. Jansen, Christina Y. Le, Leo Lu, Hui Xie, Marienke van Middelkoop, Jackie L. Whittaker   +6 more
wiley   +1 more source

Gene-centered identification of cis-regulatory islands highlights regulatory landscapes complementary to motif-centric approaches. [PDF]

BMC Genomics
Ohmori Y.
europepmc   +1 more source

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

Arthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George, George Reed, Matthew D. Kearney, Peter F. Cronholm, Kevin Kane, Jeffrey R. Curtis, Dimitrios A. Pappas, Joel M. Kremer   +7 more
wiley   +1 more source

Adipose single cell epigenome and transcriptome localize genetic risk for cardiometabolic disease and accelerated aging. [PDF]

Nat Commun
Lee SHT, Kar A, Gelev KZ, Chen ZJ, Das SS, Heinonen S, Saarinen T, Vaittinen M, Kaminska D, Peltoniemi H, Luo C, Juuti A, Männistö V, Pihlajamäki J, Kaikkonen MU, Pietiläinen KH, Balliu B, Pajukanta P.   +17 more
europepmc   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

A forward genetic screen identifies Sirtuin1 as a driver of neuroendocrine prostate cancer. [PDF]

J Exp Med
Nunes de Almeida F, Vasciaveo A, Giacobbe A, Di Bernardo M, Zou M, Antao AM, de Brot S, Rodriguez-Calero A, Chui A, Wang ALE, Floc'h N, Kim JY, Park S, Afari SN, Mukhammadov T, Ortega N, Josyula SS, Arriaga JM, Wang J, Lu J, Shen MM, Rubin MA, Califano A, Abate-Shen C.   +23 more
europepmc   +1 more source