Results 131 to 140 of about 416,036 (340)
Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis [PDF]
, 2016 Human papillomavirus induced (HPV+) cancer incidence is rapidly rising, comprising 60–80% of oropharyngeal squamous cell carcinomas (OPSCCs); while rare, recurrent/metastatic disease accounts for nearly all related deaths.
Coppock, Joseph D +8 more
core +2 more sources
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Biotechnology & Biotechnological Equipment, 2017 Cisplatin is widely used for the treatment of a variety of cancers but with a high incidence of hepatotoxicity. Baicalein is originally isolated from the root of Scutellaria baicalensis Georgi with broad bioactivities.
Chengwei Niu +4 more
doaj +1 more source
Formation of porous membranes for drug delivery systems [PDF]
, 1993 Highly crystalline porous hollow poly (-lactide) (PLLA) fibres suitable for the delivery of various drugs were obtained using a dry-wet spinning process.
Dijkstra, P.J. +6 more
core +3 more sources
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, EarlyView.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Advanced Science, EarlyView.ST6GAL1 plays a critical role in tumor progression and immune regulation in colorectal cancer (CRC). Its depletion significantly suppresses the malignant phenotype of CRC cells and enhances the efficacy of anti‐PD‐L1 therapy. High ST6GAL1 expression promotes an immune‐activated tumor microenvironment (TME), characterized by increased infiltration of ...
Ximo Xu +15 more
wiley +1 more source
The long-term effect of cisplatin on renal function [PDF]
, 1986 Paul Fjeldborg +2 more
openalex +1 more source
Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5
Advanced Science, EarlyView.Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao +9 more
wiley +1 more source
Advanced Science, EarlyView.Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao +10 more
wiley +1 more source
Metoclopramide versus metoclopramide and lorazepam. Superiority of combined therapy in the control of cisplatin-induced emesis [PDF]
, 1989 Craig J. Gordon +4 more
openalex +1 more source