Results 111 to 120 of about 256,231 (309)
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
Baicalein Sensitizes Triple Negative Breast Cancer Cells to Cisplatin by Activating Apoptosis
Natural Product CommunicationsObjective/background The potential for natural products to work synergistically with chemotherapy to reduce side effects and enhance its effectiveness has garnered significant attention.
Aya Y. Al-Kabariti +4 more
doaj +1 more source
Biotechnology & Biotechnological Equipment, 2017 Cisplatin is widely used for the treatment of a variety of cancers but with a high incidence of hepatotoxicity. Baicalein is originally isolated from the root of Scutellaria baicalensis Georgi with broad bioactivities.
Chengwei Niu +4 more
doaj +1 more source
Advanced Science, EarlyView.This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka +4 more
wiley +1 more source
Cancer Reports, EarlyView., 2023 Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada +16 more
wiley +1 more source
一系列對cisplatin具不等程度抗藥性之移型上皮癌細胞株的抗藥性機轉研究
, 2009 We explored the mechanisms of cisplatin resistance in a series of bladder transitional carcinoma cells that are either sensitive or progressively resistant to cisplatin.
侯自銓;陳淳;黃昭淵;官靜儀;呂秀慧;謝長堯;蒲永孝 +1 more
core
Advanced Science, EarlyView.ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley +1 more source
, 2014 We evaluated the efficacy of neoadjuvant docetaxel-cisplatin among 62 patients with stage III N2 non-small-cell lung cancer. Fifty-eight (94%) of 62 patients underwent surgical resection after docetaxel-cisplatin.
廖唯昱 ;陳冠宇 ;余忠仁 ;何肇基 ;施金元 +1 more
core
Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors
Advanced Science, EarlyView.This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng +12 more
wiley +1 more source
SERBP1 is required for efficient HR repair and cisplatin chemoresistance in lung adenocarcinoma
Cell Death DiscoveryResistance to cisplatin limits its clinical efficacy in LUAD patients and leads to poor prognosis. SERPINE1 mRNA binding protein 1 (SERBP1), an RNA-binding protein, is associated with tumorigenesis and progression. However, its specific role in cisplatin
Yifei Xie +10 more
doaj +1 more source