Results 91 to 100 of about 256,231 (309)

Quimioterapia con fármacos nuevos en el cáncer de pulmón de célula no pequeña avanzado [PDF]

, 2004
[spa] El cáncer de pulmón es el cáncer más frecuente en todo el mundo. A principio de la década de los 90 aparecieron varios fármacos con una actividad prometedora en cáncer de pulmón de célula no pequeña (CPCNP). El núcleo de esta tesis doctoral son dos
Cardenal Alemany, Felipe
core  

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Design, Synthesis, and Biological Activity of a Novel Non-Cisplatin-type Platinum−Acridine Pharmacophore

, 2016
Platinum−acridine conjugates were prepared from [PtCl2(ethane-1,2-diamine)] and the novel acridinylthioureas MeHNC(S)NMeAcr (6) and MeHNC(S)NMe(CH2CH2)NHAcr (15) by replacing one chloro leaving group in the cisplatin analogue with thiourea sulfur.
Elizabeth T. Martins (3012990), Cynthia S. Day (1336956), Hemanta Baruah (2685109), Gregory L. Kucera (1625605), Gilda Saluta (2148937), Ulrich Bierbach (11002), Jaroslaw Kramarczyk (3012987)   +6 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Glutathione S‐transferase omega class 1 (GSTO1)‐associated large extracellular vesicles are involved in tumor‐associated macrophage‐mediated cisplatin resistance in bladder cancer

Molecular Oncology
Bladder cancer poses a significant challenge to chemotherapy due to its resistance to cisplatin, especially at advanced stages. Understanding the mechanisms behind cisplatin resistance is crucial for improving cancer therapy.
Yi‐Cheng Pan, Pei‐Yi Chu, Ching‐Chan Lin, Ching‐Yun Hsieh, Wei‐Yu Hsu, Lie‐Fen Shyur, Juan‐Cheng Yang, Wei‐Chao Chang, Yang‐Chang Wu   +8 more
doaj   +1 more source

RETRACTED ARTICLE: RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

Journal of Biomedical Science, 2015
Background Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.
Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu, Yong-Chang Chen   +5 more
doaj   +1 more source

Phase I and Pharmacokinetic Study of Cisplatin and Troxacitabine Administered Intravenously Every 28 Days in Patients with Advanced Solid Malignancies

, 2011
PURPOSE: To assess the feasibility of administering troxacitabine, an L- nucleoside analog that is not a substrate for deoxycytidine deaminase, in combination with cisplatin, to identify pharmacokinetic interactions, and to seek preliminary evidence of ...
林家齊, LIN, CHIA-CHI
core  

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma

Cancer Cell International
Background The therapeutic effectiveness of cisplatin, a widely used chemotherapy drug for oral squamous cell carcinoma (OSCC), is often compromised by resistance, making it difficult to predict treatment outcomes.
Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi   +7 more
doaj   +1 more source

Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. [PDF]

, 2009
Contains fulltext : 79859.pdf (Publisher’s version ) (Open Access)BACKGROUND: Preoperative cisplatin alone may be as effective as cisplatin plus doxorubicin in standard-risk hepatoblastoma (a tumor involving three or fewer sectors of ...
Childs, Margaret, MORLAND B, Plaschkes, Jack, Scopinaro, Marcello, de Camargo, Beatriz, MacKinlay, Gordon, ZIMMERMANN A, Aronson, D.C., ARONSON D, Scopinaro, M., Maibach, Rudolf, Plaschkes, J., Morland, Bruce, WIDING E, DE CAMARGO B, Aronson, D., de Camargo, B., Perilongo, Giorgio, Zsiros, Jozsef, Laithier, Veronique, Widing, E., Brugieres, Laurence, PRITCHARD J, MAIBACH R, Camargo, B. de, ZSIROS J, Zimmermann, Arthur, Brugieres, L., Perilongo, G., SCOPINARO M, Czauderna, P., Zimmermann, A., Shafford, E., CHILDS M, BROCK P, Pritchard, J., Widing, Eva, Laithier, V., Brock, Penelope, Morland, B., BRUGIERES L, Roebuck, Derek, Brock, P., Childs, M., ROEBUCK D, Pritchard, Jon, Roebuck, D., Shafford, Elisabeth, Maibach, R., LAITHIER V, MACKINLAY G, PLASCHKES J, SHAFFORD E, Zsiros, J., MacKinlay, G., Czauderna, Piotr, Aronson, Daniel, CZAUDERNA P.   +57 more
core   +1 more source