Results 81 to 90 of about 284,082 (261)

Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. [PDF]

, 2009
Contains fulltext : 79859.pdf (Publisher’s version ) (Open Access)BACKGROUND: Preoperative cisplatin alone may be as effective as cisplatin plus doxorubicin in standard-risk hepatoblastoma (a tumor involving three or fewer sectors of ...
Childs, Margaret, MORLAND B, Plaschkes, Jack, Scopinaro, Marcello, de Camargo, Beatriz, MacKinlay, Gordon, ZIMMERMANN A, Aronson, D.C., ARONSON D, Scopinaro, M., Maibach, Rudolf, Plaschkes, J., Morland, Bruce, WIDING E, DE CAMARGO B, Aronson, D., de Camargo, B., Perilongo, Giorgio, Zsiros, Jozsef, Laithier, Veronique, Widing, E., Brugieres, Laurence, PRITCHARD J, MAIBACH R, Camargo, B. de, ZSIROS J, Zimmermann, Arthur, Brugieres, L., Perilongo, G., SCOPINARO M, Czauderna, P., Zimmermann, A., Shafford, E., CHILDS M, BROCK P, Pritchard, J., Widing, Eva, Laithier, V., Brock, Penelope, Morland, B., BRUGIERES L, Roebuck, Derek, Brock, P., Childs, M., ROEBUCK D, Pritchard, Jon, Roebuck, D., Shafford, Elisabeth, Maibach, R., LAITHIER V, MACKINLAY G, PLASCHKES J, SHAFFORD E, Zsiros, J., MacKinlay, G., Czauderna, Piotr, Aronson, Daniel, CZAUDERNA P., Beatriz de Camargo, Derek Roebuck, Veronique Laithier, Piotr Czauderna, Marcello Scopinaro, Jozsef Zsiros, Arthur Zimmermann, Margaret Childs, Rudolf Maibach, Eva Widing, Daniel Aronson, Elisabeth Shafford, Penelope Brock, Laurence Brugieres, Giorgio Perilongo, Jack Plaschkes, Jon Pritchard, Bruce Morland, Gordon MacKinlay   +76 more
core   +1 more source

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

MTMR6 downregulation contributes to cisplatin resistance in oral squamous cell carcinoma

Cancer Cell International
Background The therapeutic effectiveness of cisplatin, a widely used chemotherapy drug for oral squamous cell carcinoma (OSCC), is often compromised by resistance, making it difficult to predict treatment outcomes.
Kah Young Lee, Su Young Oh, Heon-Jin Lee, Tae-Geon Kwon, Jin-Wook Kim, Chang-Geol Shin, Su-Hyung Hong, So-Young Choi   +7 more
doaj   +1 more source

RETRACTED ARTICLE: RNA interferences targeting the Fanconi anemia/BRCA pathway upstream genes reverse cisplatin resistance in drug-resistant lung cancer cells

Journal of Biomedical Science, 2015
Background Cisplatin is one of the most commonly used chemotherapy agent for lung cancer. The therapeutic efficacy of cisplatin is limited by the development of resistance.
Chun-Hua Dai, Jian Li, Ping Chen, He-Guo Jiang, Ming Wu, Yong-Chang Chen   +5 more
doaj   +1 more source

AKR1C1 controls cisplatin-resistance in head and neck squamous cell carcinoma through cross-talk with the STAT1/3 signaling pathway

Journal of Experimental & Clinical Cancer Research, 2019
Background Cisplatin is the first-line chemotherapy used against most upper aerodigestive tract carcinomas. In head and neck cancer, sensitivity to cisplatin remains the key issue in treatment response and outcome. Genetic heterogeneity and aberrant gene
Wei-Min Chang, Yu-Chan Chang, Yi-Chieh Yang, Sze-Kwan Lin, Peter Mu-Hsin Chang, Michael Hsiao   +5 more
doaj   +1 more source

Phase I and Pharmacokinetic Study of Cisplatin and Troxacitabine Administered Intravenously Every 28 Days in Patients with Advanced Solid Malignancies

, 2011
PURPOSE: To assess the feasibility of administering troxacitabine, an L- nucleoside analog that is not a substrate for deoxycytidine deaminase, in combination with cisplatin, to identify pharmacokinetic interactions, and to seek preliminary evidence of ...
林家齊, LIN, CHIA-CHI
core  

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Glutathione S‐transferase omega class 1 (GSTO1)‐associated large extracellular vesicles are involved in tumor‐associated macrophage‐mediated cisplatin resistance in bladder cancer

Molecular Oncology
Bladder cancer poses a significant challenge to chemotherapy due to its resistance to cisplatin, especially at advanced stages. Understanding the mechanisms behind cisplatin resistance is crucial for improving cancer therapy.
Yi‐Cheng Pan, Pei‐Yi Chu, Ching‐Chan Lin, Ching‐Yun Hsieh, Wei‐Yu Hsu, Lie‐Fen Shyur, Juan‐Cheng Yang, Wei‐Chao Chang, Yang‐Chang Wu   +8 more
doaj   +1 more source

Dosisabhängigkeit der Cisplatin-Ototoxizität

, 2009
Cisplatin ist ein hochwirksames Chemotherapeutikum für die Behandlung unterschiedlicher Tumoren im Kindesalter. Als Nebenwirkung kann ein Hörverlust, beginnend im Hochtonbereich auftreten.
Schmidt, CM, Schmücker, M, Deuster, D, Boos, J, am Zehnhoff-Dinnesen, A, Jürgens, H, Lanvers-Kaminsky, C   +6 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source