Results 1 to 10 of about 103,668 (166)
The Role of Tumour Metabolism in Cisplatin Resistance [PDF]
Frontiers in Molecular Biosciences, 2021 Cisplatin is a chemotherapy drug commonly used in cancer treatment. Tumour cells are more sensitive to cisplatin than normal cells. Cisplatin exerts an antitumour effect by interfering with DNA replication and transcription processes.
Lude Wang +4 more
doaj +3 more sources
Mitochondrial Involvement in Cisplatin Resistance [PDF]
International Journal of Molecular Sciences, 2019 Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic option for several tumors. Circumventing cisplatin resistance remains, therefore, a major goal for clinical therapy and represents a challenge for scientific research.
Veronica Cocetta +2 more
exaly +4 more sources
SOX4 induces cisplatin resistance in cervical cancer cells by inhibiting aerobic glycolysis [PDF]
Cell Death DiscoveryCisplatin resistance remains a major cause of chemotherapy failure in cervical cancer. Although our previous work identified that SOX4 promotes cisplatin resistance in cervical cancer cells, the underlying mechanism has not been fully elucidated.
Ruili Sun +8 more
doaj +2 more sources
Cisplatin Resistance: Genetic and Epigenetic Factors Involved
Biomolecules, 2022 Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the ...
Yuliannis Lugones +2 more
doaj +3 more sources
Long non-coding RNA LINC00346 contributes to cisplatin resistance in nasopharyngeal carcinoma by repressing miR-342-5p [PDF]
Open Biology, 2020 Cisplatin has been used as the first-line chemotherapy to treat advanced nasopharyngeal carcinoma (NPC), while acquired cisplatin resistance resulting from epigenetic regulation is not well understood. The relative expression of LINC00346 was detected in
Zheqing Cui +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Chemoresistance is the major restriction on the clinical use of cisplatin. Aberrant changes in protein glycosylation are closely associated with drug resistance.
Wenjuan Zeng +12 more
doaj +1 more source
HNF4G increases cisplatin resistance in lung adenocarcinoma via the MAPK6/Akt pathway [PDF]
PeerJ, 2023 Background Lung adenocarcinoma is one of the most common tumors, and cisplatin is frequently used in treating lung adenocarcinoma patients. This study aimed to look into the roles and mechanisms of HNF4G in cisplatin resistance of lung adenocarcinoma ...
Jiaqi Liang +11 more
doaj +2 more sources
Cancer Medicine, 2023 Background Cisplatin resistance is among the main reasons for the poor prognosis of ovarian cancer (OC) patients. Until now, effective biomarkers for predicting cisplatin resistance in OC and specific drugs for reversing this resistance are lacking. This
Qingsong Zeng +5 more
doaj +1 more source
BMC Medicine, 2022 Background Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment
Tong Tong +10 more
doaj +1 more source
FAM83B inhibits ovarian cancer cisplatin resistance through inhibiting Wnt pathway
Oncogenesis, 2021 Cisplatin resistance is frequently occurred in ovarian cancer therapy, understanding its regulatory mechanisms is critical for developing novel treatment methods and drugs.
Shanyang He +7 more
doaj +1 more source